Our PhD program is now open to applications for 2025 admissions. Too much cool science to summarize, take a look and apply! Deadline Jan 7th.

USP10 emerges as a unique therapeutic target in APC-truncated #ColorectalCancer 🔬nature.com/articles/s4138… @diefenbacherlab.bsky.social #OpenAccess

We congratulate Michaela Reissland and the whole team in Markus Diefenbacher's lab on their new paper in Oncogene. In the study, they were able to demonstrate the role of USP10 in Wnt signalling in colorectal cancer models. Thank you for the opportunity to contribute.

So proud of my first first-author paper🥳Can´t be more grateful to all who contributed wrapping up my PhD project to this great story! Little thread about our most important finding will follow soon🧵

🚨 Check our latest paper in Oncogen! By combining #proteomics, #spatialtranscriptomics #AlphaFold #organoids and innovative in vivo CRISPR-induced intestinal tumor models, we identified USP10 as a new vulnerability colorectal tumors. Check it out here: rdcu.be/dYz2U

Excited to share our latest research published in Science Magazine! Cryptic splicing can lead to proteotoxic stress, but how do cells cope? Our study uncovers the role of ubiquitination and ER-phagy in mitigating the effects of misfolded proteins. science.org/doi/10.1126/sc…