🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

vu128, the variable integer serialization format, is about 5x faster than leb128 because it doesn't branch as often leb128 is a poor fit for modern CPUs

A decade ago, we had thousands of bacterial genomes. Now, we have millions. How to scale computational methods? Our paper in Nature Methods answers this: use evolutionary history to guide compression and search. …From terabytes to tens of GBs… w/@Baym Zamin Iqbal et al. 🧵1/

QuickSort has been synthesized! I've finally added varlen uints to NeoGen, and, for the first time ever, it has invented, on its own, an O(n*log(n)) sorting algorithm! NeoGen isn't an AI. There is no model, no pre-training, no previous knowledge of sorting. In fact, the system

Congrats to my colleague and collaborator @BenLangmead–our 2012 paper on Bowtie2, nature.com/articles/nmeth…, ranks 29th on the most-cited papers of the 21st century nature.com/articles/d4158…

There are so many weird Biology quirks that I somehow missed before and am only just finding now... Apparently translation can and *does* initiate from EVERY codon With the caveat that any codon other than the canonical AUG / GUG / UUG options induce transcription at such

I'm getting increasingly convinced that 95.4% of all software engineering problems are because 1) latency is highs and 2) people code like latency is low. Let me get through a couple of examples:

Do competitive programming. It’s the best investment of your time to get a great job in tech.

Universities have no clue what industry needs. Industry does not know what it needs. Government would be the last to know. We wrongly attribute the title of 'expert' to people who have no clue, no actual expertise... We confuse power and authority with expertise. Wherever you

In the past, one of the main excuses for shipping slow experiences was, in 1-2 years computers will be faster, so it will fix itself. Computers mostly stopped getting faster, and everyone forgot this was the linchpin that made the strategy work. Thus they will keep doing this

STOP. NESTING. EVERYTHING. User interfaces were meant to be FLAT and dense. Not whatever this terrible redesign is. Your sidebar *should* scroll reasonably. The old "Explore" button is a nice example of this, everything can be in view at the same time. With the new UI? 2 clicks

"sub-second lookup" on a computer is mostly akin to "sub-week quarter mile" on a race car

🖥️🧬 WABI '25 will not only have excellent keynotes, but an exciting program of papers. The titles and abstracts of all accepted WABI '25 papers are now available on the conference website (wabiconf.github.io/2025/talks/). I'm looking forward to seeing these talks!

Compressing and accelerating exabytes of pangenomic data - Summer School & Hackathon docs.google.com/presentation/d… #pangenomics

I was honored to deliver the keynote address at the 23rd Symposium on Experimental Algorithms (SEA 2025). My talk, “Algorithms for Modern Processor Architectures,” explored key topics including superscalar execution and SIMD instructions, highlighting their critical influence on

Slack is becoming so ran thru. MS Teams is a non-starter. Discord is gamer slop. I just want channels, threads, and DMs. Like nothing else. Why does every product tend towards slop like this?

your job here at github is to replace the browser's native "find" feature with an implementation in react. you need to make sure that shift+enter doesn't go backwards, and the latency when you hit enter must be at least 1 second