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Being open to new ideas isn’t just a virtue in science, it’s a necessity. Progress often comes not from having the right answers, but from asking the right questions and being willing to rethink what we thought we knew.

Too much competition in science leads to over-optimizing the metrics of success (publications, funding, etc.) at the expense of actual good science. It's Goodhart's law. Here's a post I wrote on it before I heard of Goodhart's law: maketheworldworkbetter.wordpress.com/2013/04/03/wha…

Yes! mRNA is not a measure of protein abundance, it is part of a buffering system that adjusts protein abundance. If protein is low, make more mRNA, and vice versa, so mRNA can often (but not always) tell the opposite story!

Such cool cover art, from a 4-year old!

I've been saying exactly this, less elegantly, for a while. Life is fundamentally information and complexity. It's the evolutionary selection for function that drives an inexorable increase in complexity in open systems.

Exactly! The energy is needed to maintain the information/complexity. This is life... and the basis for health in living organisms.

Excellent work from our colleague Jack Rowe. It's easy to forget that the best way to achieve healthy aging is not through pills, it's through solid public health and prevention throughout the lifecourse, for everyone across the income spectrum.

So proud to have contributed to this amazing work by Jack Devine and Martin Picard. There aren't generally "low-mitochondria" and "high-mitochondria" people - we differ on where we have them more than how much. But why?! So cool.

Another view on this amazing paper!

Hitting the nail on the head. There is no free lunch in evolution. A simple tweak that evolution could have found cannot be a simple net positive for us.

Amazing new research from Diego Bassani: We can map networks of communities to see how ideas, diseases, and many other things spread. This produces a crucial new tool, SEEDNet, for public health research. So cool! communities.springernature.com/posts/the-netw…

One of the hardest tasks as a scientist is to not just confirm our own biases. We can intentionally cherr-pick to lie, but this is rare - the bigger risk is that we don't know we're doing it. Careful data science is about learning not to do this.

Have you ever thought about how light moves through the brain? So amazing that that there are brain structures that guide this. We are constantly uncovering new layers of biological organization, so humility should be the rule for our understanding of biology!

Whatever you think about RFK Jr., this is unqualified good news. Not yet clear how big the health benefits will be, but more than nothing! nytimes.com/2025/06/17/bus…

Yet more proof that we cannot think simplistically about the roles of biological molecules. The pro- and the anti- are often context dependent, and it has to be structured that way for the system to maintain balance efficiently!