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Cyrus Tau and I are so excited to share our work on developing a CRISPR protein-guided, trans-splicing system for making versatile RNA edits!!! See the highlights in Cyrus' thread and the preprint for details!

We demonstrate efficient, specific, and programmable trans-splicing of multi-kilobase RNA cargo into nine endogenous transcripts in 2 human cell types Congrats to co-lead authors Sita Chandrasekaran and Cyrus Tau in the lab! Check out their tweet thread below x.com/cyrus_tau/stat…

Nice work! “The RESPLICE of Life” #Splicing #TranSplicing #CRISPR #Technology #Editing

Excited to share this new work from Arc Institute-- led by graduate student Sita Chandrasekaran and undergrad Cyrus Tau with Patrick Hsu. Building on our previous work on Cas13d-based RNA targeting we can now write full sequences into endogenous RNA!

Let’s go Cyta!!🚀 Cyrus Tau Sita Chandrasekaran

Long non-coding RNAs comprise a large part of the genome, yet loss of one copy (haploinsufficiency) of a lncRNA is not known to cause a human disease. Read our preprint to learn how deletions of the lncRNA CHASERR cause a severe neurodevelopmental disorder.medrxiv.org/content/10.110…

Nice story in Endpoints News on our lab's RNA writing work by Ryan Cross the Science Boss, alongside complementary studies from friends and colleagues!

Brian Hie Preprint is now on BioRxiv! biorxiv.org/content/10.110…

me in lab

Our most recent preprint on #DeltaSplice for quantitative prediction of splicing and splicing-altering mutations. Great collaboration with Tao Jiang Lab. Led by Chencheng Xu@Jiang lab and a former postdoc Suying Bao in my lab. Software available soon-stay tuned!

Excited to share our work published in Science Magazine today answering the question: “Where does Cas13 come from?” science.org/doi/10.1126/sc…

The upper middle class yearns for public transit but without poor people

🧵 Really excited to share our new paper! As species diversify, sex pheromones rapidly change, but how do male mating circuits co-evolve to guide mate choice? A thread on circuit evolution & mating strategy... 1/9 nature.com/articles/s4158…

A nature study from the #FriedmanLab identifies a new neural circuit that connects a hunger-signaling hormone to jaw movements. Manipulating the circuit can either curb appetite or spur massive overeating. #RockefellerScience rockefeller.edu/news/36813-the…

🧵Epigenetics require the coordinated interplay of diverse proteins and mechanisms. To systematically explore this, we invented the COMBINE platform to quantify the effect of >50,000 pairs🧦of long epigenetic effectors on endogenous human transcription biorxiv.org/content/10.110…

🧵In new work, we report a systematic engineering roadmap to optimize large serine recombinases (LSRs) for direct, site-specific insertion into the human genome 🧬. We achieved over 50% insertion efficiency and 97% genome-wide specificity, a 10X improvement over our previous work

Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from transgene expression and real-time

Our latest study is available as a preprint. We show that psychedelics induce subtle changes in gene expression but robust changes in alternative splicing lasting at least one month, suggesting that alternative splicing may represent a general mechanism for prolonged plasticity.