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Super happy to see our paper on #AMR out in Nature Communications ! 🤩 Thanks to Tiago Costa Himani Amin at CBRB Imperial Sciences Imperial Life Sciences for great teamwork! Below a brief summary of what we found out👇 You can read the whole thing here: nature.com/articles/s4146…

Happy birthday to the boss José R Penadés 🎉🎂 Laterally transducing into the next year 🧫🧬

Sedentary chromosomal integrons (SCIs) are biobanks of anti-phage defence systems! In a huge collaboration with the Didier Mazel lab, we showed that these flexible genetic platforms encode known defences and further discovered 16 new systems. A thread (1/n) doi.org/10.1101/2024.0…

Happy to see our paper out @nature today: A bacterial immune system conjugates ubiquitin-like proteins to phage tails. This generates non-infective virions Congrats Jens Hör & Sharon Grayer Wolf! Link to paper: tinyurl.com/Isg15 Read the thread: x.com/SorekLab/statu…

Threeled to announce: promotion of my day-2-day supervisor Jakob T Rostøl who today has commenced his first of many PI positions as Imperial College Research Fellow following the footsteps of the fumador scientist Alfred Fillol who invited me to join my first PI meeting.

It’s just a tiny bottle.. It probably doesn’t smell that bad Tiny Bottle:

Thrilled to share my first first-author paper is out today Nature Communications !nature.com/articles/s4146… We discovered a new anti-phage system family, Tail assembly inhibition (Tai), found in 17 species.

Latest from the lab! PICI and prophage-encoded Tai proteins protect cells by blocking phage tail assembly. Prophages counter with a mechanism allowing tail formation after induction. Defence and counter-defence genes are organised for expression. nature.com/articles/s4146…

It is really great to have an opportunity to share my work in phage annual conference. The university of Oxford is really beautiful. #PhgOx24

My PHirst PHage conPHerence!! Am super thankful for the opportunity to yap, learn, and connect with other amazing phage enthusiasts!! #PhgOx24 Bacteriophage Oxford

Multiplexed editing of phage genomes using retrons, now published at Nature Biotechnology with lots of new bells and whistles. chloe kate crawford Santi Bhattarai-Kline Darshini Poola Karen Zhang Alex González-Delgado Matías Rojas Montero nature.com/articles/s4158…

From bacteria to human immunity! On our quest to idendify eukaryotic homologs of antiphage systems, we discovered a family of SIR2 immune proteins widespread in eukaryotes. We show that a human homolog, SIRanc, is a novel actor of the TLR pathway. biorxiv.org/content/10.110… 🧵👇

Two years ago we published the discovery of hotspots of novel anti-phage defense systems in the genome of P4 phage satellites, including a mysterious Phage Anti-Restriction Induced System (PARIS). We have now published the mechanism in nature nature.com/articles/s4158…

Great work @Thomasipoutch, hope you all flock to read this amazing story on how CRISPR evolves as the bacteria moves from one host to another!

There's only one right answer.

Virtual Virology is back - our first ever phage session. Do join us...

So happy to share my work José R Penadés lab 🤩 We investigated the efficiency of HGT mechanisms in S. aureus🧬, finding that LT is the most efficient one, and that strains defective in immune systems🛡️act as gateways for inter-clonal complex HGT🔀 biorxiv.org/content/10.110…