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Everyone should apply to be a part of this brilliant new HMS lab. Huge congrats Luke!

Out today nature – our analysis of the influences of common nuclear DNA variation on mitochondrial DNA copy number and heteroplasmy across >250,000 people across two biobanks! disq.us/t/4ibyjjo

I'm delighted to release the first half of my new open-access online textbook in human population genetics: web.stanford.edu/group/pritchar…

Can we precisely rewrite the genetic code - make a single DNA spelling change - in the liver of a human being for clinical effect? YES! Scientific milestone: VERVE-101 provides first proof-of-concept for in vivo DNA base editing in humans Clinical implication: It’s early

Wegovy is effective, but no Medicare coverage. Easy to assume because of high $. But all obesity meds = 30y restriction. Today in STAT, I discuss how ban emerged in a very different environment and argue we should recognize origins of status quo. statnews.com/2024/01/08/wei…

We've noticed some common missteps when using Burden Heritability Regression (BHR) If you're using BHR, take a look at this new FAQ to avoid them! github.com/ajaynadig/bhr/…

Great NEJM review on how human training and use influence output of medical AI

Just as most heritability resides in variation ⬇️ genome-wide significance thresholds, so exists meaningful transcriptional variation in genes individually not identified as a genomewide sig. This new method TRADE from Ajay Nadig Luke O'Connor characterizes those effects!