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Why does cancer incidence increase with age? Is it the accumulation of mutations? Is it declining immune system? Is it other factors? This PNAS article emphasizes the role of immune system decline over mutation accumulation. 1/2

everything we’ve been told about aging may be wrong scientists just discovered that the “biological clock” tracking your aging isn’t actually controlling it, it’s just reporting the damage. the real driver of aging are permanent dna mutations 1/

The 10 most striking Kaplan-Meier curves (that I have seen) 🧵 1. Dual GLP1/GIP agonist, Tirzepatide, for prevention of type 2 diabetes in people with obesity It's easy to miss the dark blue line (15 mg group), because it never leaves the X axis:

Some types of cell are more likely than others to give rise to tumours. A rapid cell cycle is a newly identified predictor of cancer susceptibility. go.nature.com/42V5GAM

An innovative genome-editing tool promises to do what original CRISPR systems have struggled to achieve: insert entire genes, precisely and efficiently, into human DNA go.nature.com/430GeeB

A clinical trial using engineered CAR-T cells to hunt cancer cells has reported impressive results for solid tumours go.nature.com/3SRNOCx

This is a major story from #ASCO25. Randomized phase 3 trial of time of day of immunotherapy infusion. Randomized to infusion before or after 3pm. Early infusion far superior: PFS 11.3 vs 5.7 HR 0.42, OS HR 0.45! Impactful, pragmatic, not costly. This should be a bigger story.

same data

Top 5 advances in medicine in May (🧵) 1. A record-breaking genetic therapy This bespoke CRISPR therapy was tailored for one patient's mutation, breaking two records: the first personalised gene editing, and (possibly) the fastest a medicine's ever been produced There's a

Spectacular work from ⁦Parker Institute for Cancer Immunotherapy⁩ investigator ⁦Dr Marcela Maus⁩ IFN-γ–resistant CD28 CAR T cells demonstrate increased survival, efficacy, and durability in multiple murine tumor models | STM ⁦Mass General Brigham⁩ #CellTherapy science.org/doi/10.1126/sc…

A group of research-integrity experts has launched a toolkit for researchers that outlines how to spot suspicious scientific papers. go.nature.com/45jRa8C

When do girls fall behind in maths? Gigantic study pinpoints the moment nature.com/articles/d4158…

It’s a hefty 206-page research paper, and the findings are concerning. "LLM users consistently underperformed at neural, linguistic, and behavioral levels" This study finds LLM dependence weakens the writer’s own neural and linguistic fingerprints. 🤔🤔 Relying only on EEG,

Prevention beats cure, which is why it's so exciting that Lenacapavir, a twice-yearly HIV preventative, just got approved for the first time (by the FDA) Why is it such a big deal? When trialled (in women in South Africa and Uganda) there were 0 HIV infections 🧵

This should be required reading by all graduate students and postdocs | A brief guide to statistical analysis of grouped data in preclinical research nature.com/articles/s4225…

So you want to change transgene expression: just change your promoter, right? Changing the promoter increases RNA and thus protein levels. What more could be happening? [1/n] Well, promoters don’t just set RNA levels; they uniquely transform how RNAs are transmitted into protein

🚨New paper on theories of ageing I discuss the major mechanistic theories of ageing in light of recent findings as well as the fundamental nature of the ageing process. Theoretical work is more important than ever in biology, including in ageing. nature.com/articles/s4155…

Bioengineered immunocompetent preclinical trial-on-chip tool enables screening of CAR T cell therapy for leukaemia. #Tcell #immunotherapy #organonachip 🧪nature.com/articles/s4155…

Nature research paper: Mitochondrial origins of the pressure to sleep go.nature.com/40nFRZM

Review JCI insight Enhancing the potency of CAR-T cells against solid tumors through transcription factor engineering insight.jci.org/articles/view/…