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🚨New preprint🚨 Adeno-associated virus 2 infection in children with non A-E #Hepatitis A case-control investigation of 9 early cases in #Scotland & 58 controls. MRC-Uni of Glasgow Centre for Virus Research Public Health Scotland Royal Hospital for Children, Glasgow ISARIC4C UCL UK Health Security Agency Emma Thomson 🧵1/ medrxiv.org/content/10.110…

In Xpert-positive TB-patients, we compared the aerosolization of M. tuberculosis between deep breathing, normal breathing, and induced coughing.

We found that, per manoeuvre, coughing released more M. tuberculosis than breathing, however, individuals breathe 22,000 times per day compared to an average of ~460 coughs.

Therefore, we estimate that breathing alone is likely to contribute around 90% of the daily aerosolized M. tuberculosis bacilli.

Findings of the RADIANT-TB trial led by Rulan Griesel and Gary Maartens in Cape Town, presented this week at AIDS2022, evaluating dolutegravir dosing in patients with TB on rifampicin:

Increasing numbers of patients accessing OPAT services (OPAT/COPAT) across Scotland - on average 250 people per week 2/

Rifampicin-resistant TB independently predicts death in patients hospitalised with HIV-associated TB. Why is this the case? We set to find out in a study just published in Southern African Journal of HIV Medicine sajhivmed.org.za/index.php/hivm…

20+ years building this service , an amazing achievement 🙌

#Mastodon account scicomm.xyz/web/@davidadam…

EXC The 'life-saving' service set to keep hundreds of patients out of hospital every week heraldscotland.com/news/23250155.…

Helen McArdle Thanks for this! More info on #OPAT in Scotland here sapg.scot/guidance-qi-to… SAPG Fran Kerr

Free Chapter 1 from How to Request a Test until the end of February. Todd C. Lee Emily McDonald Brad Spellberg see what you think and if you'd like a copy of the whole book. academic.oup.com/book/45509/cha…

#CROI2023: Treatment for tuberculosis, a leading cause of death worldwide, typically involves 6 months of continuous therapy. In the TRUNCATE-TB trial, a strategy involving shorter initial treatment was noninferior to standard treatment. nej.md/3XsQB4H

Clinician scientists should read this

Following up on my post from yesterday, some examples. I’ll bring the marshmallows. elevanth.org/blog/2023/06/1…

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Everyone who intends to join or lead a research group should read the essay by Bruno Lemaitre: An Essay on Science and Narcissism: How do high-ego personalities drive research in life sciences? (Usually available for free download; do a google search)

Revelation, Resistance, Reexpression, and Residual: A course in Exploratory Data Analysis from Jim Albert, inspired by John Tukey's book on the topic. bayesball.github.io/EDA/