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It has never been this easy to differentiate #FalseMorels from #Morel. Our sensitive and accurate assay can let you enjoy the #EdibleFungi without any apprehension! Presenting our collaborative study with #Jameslab UMLifeSciences tandfonline.com/doi/abs/10.108…

Cool paper and molecules! .Marc Chevrette can you please share how the strain library was generated? Metabolomics and Genomics Enable the Discovery of a New Class of Nonribosomal Peptidic Metallophores from a Marine Micromonospora pubs-acs-org.proxy.lib.umich.edu/doi/10.1021/ja…

Congratulations on this outstanding work by Vikram Shende @nataliaaarose Jacob Sanders and team! Molecular Dynamics Simulations Guide Chimeragenesis and Engineered Control of Chemoselectivity in Diketopiperazine Dimerases onlinelibrary.wiley.com/doi/10.1002/an… UMLifeSciences U-M College of Pharmacy CCHF

Very nice article by @madelinerb2 Using Bacterial Toxins to Foster Human Health | ASM.org asm.org/Articles/2022/…

Great to have Dr. Brian Curtis join our group UMLifeSciences. Welcome Brian!!

Thank you to Professor Roger Cone, the Scientific Advisory Committee and the faculty, staff, students and postdoctoral fellows UMLifeSciences for a tour and stimulating discussions today.

You still have time to apply to the University of Michigan Pharmacy Postdoctoral Collegiate Fellows Program, a program intended to increase representation of future faculty in #STEM! Learn more and apply here: myumi.ch/6NA83

Congratulations Greg!! Regents appoint five 2023 Arthur F. Thurnau Professors record.umich.edu/articles/regen…

Congratulations Carsten and Yindi, and all co-authors, especially Swathi and Chris's teams at UFlorida! pubs.acs.org/doi/10.1021/ja…

Over 20 years ago, Bill Gerwick GerwickLab and I proposed this unusual biosynthetic route involving a single carbon truncation. Great to see the proof. Enzymatic α-Ketothioester Decarbonylation Occurs in the Assembly Line of Barbamide for Skeleton Editing pubs.acs.org/doi/10.1021/ja…

A new review article by Martin Grininger (@Grininger_Lab) explores the enzymology of modular polyketide synthases. Free to read: rdcu.be/c7vZC nature.com/articles/s4158…

Excited to announce the newest publication from dissertation work! We know Microcystis can produce microcystins, but what else might they be making in blooms? Greg Dick David H. Sherman Ashu Tripathi journals-asm-org.proxy.lib.umich.edu/doi/full/10.11…

Congratulations to Maribel EK Okiye on her fascinating new study relating metabolomics and human health/dysbiosis using a well established clinical model. Investigating Metabolic Trends in the Oral Cavity to Identify Novel Metabolites biorxiv.org/content/10.110…

Very proud of Hannah Boesger selection as a trainee in the UM Pharmacological Sciences Training Program. She is exploring new computational approaches for biocatalyst discovery directed toward antibody drug conjugate payloads in target cancer therapy. UMLifeSciences U-M College of Pharmacy

Congrats to Hanna, Autumn, Sarah and Morgan for developing a new data science workflow to predict enzymatic performance. It was great working the amazing @HysterLab on this long-term project! pubs.acs.org/doi/abs/10.102…

Very nice work to expand our understanding of this important class of CYP450s! Exploring the Diverse Landscape of Biaryl-Containing Peptides Generated by Cytochrome P450 Macrocyclases | Journal of the American Chemical Society pubs-acs-org.proxy.lib.umich.edu/doi/full/10.10…

Congratulations to Maria, wonderful work! Our first foray into directed evolution, super fun. Directed Evolution of a Modular Polyketide Synthase Thioesterase for Generation of a Hybrid Macrocyclic Ring System | ChemRxiv - go.shr.lc/49j6ctZ @MariaLAdrover UMLifeSciences

Congratulations to Hannah Boesger for her outstanding talk yesterday in the The Catalysis Innovation Consortium and collaboration with the Ken Houk lab and Jacob Sanders! Facing new challenges in CYP450s as late-stage C-H oxidation biocatalysts and moving the innovation needle in new and surprising ways.

A team led by U-M College of Pharmacy has identified a new mechanism by which plants generate molecules that have potential pharmaceutical activity. Working with the LSI's Janet Smith, the team used X-ray crystallography to study the protein structures and uncover novel plant

Team+++! Structure–Activity Relationships of Natural and Semisynthetic Plecomacrolides Suggest Distinct Pathways for HIV-1 Immune Evasion and Vacuolar ATPase-Dependent Lysosomal Acidification | Journal of Medicinal Chemistry pubs.acs.org/doi/full/10.10… UMLifeSciences U-M College of Pharmacy