improving biology that evolution has optimized is absurdly difficult. one reason for optimism in longevity is that evolution hardly selected for it. even simple interventions can restore function or extend life. it seems likely that medicines turning on just a few key genes can

.Jacob Kimmel thinks he can find the transcription factors necessary to reverse aging. 0:00:00 – Three reasons evolution didn't optimize for longevity 0:12:48 – Why didn't humans evolve their own antibiotics? 0:26:08 – De-aging cells via epigenetic reprogramming 0:45:24 – Viral

How can we combine the exquisite function of natural receptors with the programmability of synthetic biology? Check out this exciting new story led by Hailey Edelstein and Amparo out today in Nature Chemical Biology

At OpenAI, we believe that AI can accelerate science and drug discovery. An exciting example is our work with @RetroBiosciences, where a custom model designed improved variants of the Nobel-prize winning Yamanaka proteins. Today we published a closer look at the breakthrough. ⬇️

A major win for solid tumors; GD2 #CART mediated a 40% complete remission rate in children with high-risk neuroblastoma Nature Medicine ! nature.com/articles/s4159…

This is so interesting. The conversion of CS into biology continues.

Thank you for sharing our microglia replacement study! In 2020, we achieved efficient microglia replacement for the first time (PMID: 32783928). After that, we took another 5 five years to demonstrate its clinical feasibility and efficacy. We truly believe that microglia

Exciting to see our protein binder design pipeline BindCraft published in its final form in nature ! This has been an amazing collaborative effort with Lennart, Christian Schellhaas, Sergey Ovchinnikov, Bruno Correia and many other amazing lab members and collaborators. nature.com/articles/s4158…

BioFuse: A programmable timer switch of gene expression "Sequential ABE edits create new PAM sites, progressively activating the downstream segments of the fuse-like DNA sequence, enabling ABE to modify the −35 box of the downstream promoter" science.org/doi/full/10.11…

One of the most epic framings of human genetics that lives rent-free in my head: "The human population, through explosive growth, has performed a comprehensive saturation mutagenesis experiment on itself. It is now the case that any single base substitution that is compatible

Faculty job cycle is upon us, here are some notes on the process in case they are helpful: arjun-raj-lab.gitbook.io/arjun-rajs-too…

Very impressed with the work of Norn Group and Impetus so far, and their thoughtful and bold approach to funding & accelerating longevity research.

Now some of the downsides of my experience with "vibe-coding for serious work". First, recap the good sides I mentioned previously: it's amazing at quick prototyping things, making tiny throw-away hyper-specialized demos, taking care of boilerplate, setup, and writing tests for

What a life in science. RIP. nytimes.com/2025/09/07/sci…

As de novo pMHC binders become commodity, the role of the wild type TCR starts to evolve. Both have their place, but lately it feels like all progress was in binders. No longer. Pleased to report that the first AI-TCR against a non-viral epitope has been achieved TCR-TRANSLATE🧵

Earlier this year, I learned I have a pathogenic variant in BRCA2, which gives me a very high lifetime risk of breast cancer (55-69%), as well as an increased risk of ovarian cancer (12-29%) and pancreatic cancer (5-10%). 🧵1/ …

Welcome to the age of generative genome design! In 1977, Sanger et al. sequenced the first genome—of phage ΦX174. Today, led by Samuel King, we report the first AI-generated genomes. Using ΦX174 as a template, we made novel, high-fitness phages with genome language models. 🧵