🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Diego @MTorrescnic David Sancho CNIC CNIC BIoIT Hopefully many people will be using our new tool, as they already did with the original digitalDLSorter, pioneer work using deep learning on scRNASeq data for deconvolution on bulk rnaseq frontiersin.org/journals/genet… We keep on working to improve their performance! 💪🏻💪🏻💪🏻

Congrats our favorite Bioinformatician, Diego Mañanes Diego on your first PhD publication led by Fatima Sanchez-Cabo & all the bioIT CNIC!!! A new method for #deconvolution of #spatialtranscriptomics data in #Bioinformatics 👏👏👏

Apply now for one of our Summer student fellowships for a la internship! 👇👇👇

Local heterogeneity of tissues can define their function and predict clinical outcomes. We introduce Kasumi 💻biorxiv.org/content/10.110… to identify spatially localized neighborhoods of intra and intercellular relationships from spatial omics persistent across samples & conditions

Writing this piece has been quite fulfilling (and scary). I spent half of last year putting in order some of my thoughts regarding how to study multicellular coordination with single-cell and spatial data. If you are interested please read the manuscript below. 😊

What a PERFFect day to share our new preprint! With Tsion Abay #BobStickels Meril Takizawa @ChaligneRonan and Ansu Satpathy, we introduce PERFF-seq, a new experimental approach to studying rare cells with scRNA-seq via transcript-specific enrichment. biorxiv.org/content/10.110… 1/n

Álvaro García from the MechanoCaveoLab together with Diego Mañanes from David Sancho kick off the #AtheroConvergence HR20 CaixaResearch closure meeting in beautiful Donostia CIC biomaGUNE CNIC YaleVBTProgram Yale University Aarhus Universitet

🚨FREE LINK to our latest review on metabolism of tissue macrophages depending on LOCATION AND AGE: authors.elsevier.com/a/1j6Zt3jDgWq3… Tissue-resident #macrophage #metabolismis diverse across organs to support distinct tissue functions. #Aging deregulates this balance: #inflammaging

Are you interested in the mathematics behind deep generative models and how they can be applied to get meaningful insights from single-cell omics? This is your review! CNIC CNIC BIoIT @MTorrescnic SEBiBC sciencedirect.com/science/articl…

Our workflow, FLOP, exploring the impact of filtering, normalization, and differential expression on functional analysis is now published in Nucleic Acids Res. doi.org/10.1093/nar/gk…

Understanding complex diseases requires approaches that jointly analyze omic data across multiple biological layers. In our new preprint, we merge data-driven multiomic factor analysis with systematic integration of mechanistic knowledge using COSMOS+ 🧵👇 doi.org/10.1101/2024.0…

Glad to be presenting academic.oup.com/bioinformatics… spatialDDLS as a highlight talk at the #ECCB2024 in beautiful #Turku Diego CNIC BIoIT CNIC

CNIC BIoIT CNIC at the #congresosebibc2024 SEBiBC ❤️

📢 Introducing CORNETO: a unified, knowledge-driven framework for multi-sample network learning & modeling via constrained optimization, supporting a wide variety of network methods and prior knowledge 💻Code: github.com/saezlab/corneto 📜Paper: doi.org/10.1101/2024.1… 🧵👇

Online now: Microbiota translocation following intestinal barrier disruption promotes Mincle-mediated training of myeloid progenitors in the bone marrow dlvr.it/THWLn9

OPEN Immunity cell.com/immunity/fullt… Fat diet, dysbiosis, pathogens, inflammation & chemicals induce gut barrier disruption! We find that systemic dissemination of gut microbiota mediates a Mincle-dependent induction of trained immunity in myeloid bone marrow cells (1/8)

Revolución en la medicina: una molécula producida por bacterias del intestino causa la aterosclerosis, culpable de millones de muertes. El descubrimiento, del David Sancho, se acaba de publicar en la revista nature 👇 elpais.com/salud-y-bienes…

💥 A gut microbe metabolite that drives #atherosclerosis? Yes—Imidazole propionate (ImP) triggers vascular inflammation without changing cholesterol. 🧪 We show the pathway—and how to block it. nature.com/articles/s4158… #OpenAccess at nature CNIC #microbiome #CVD

1/12 Revolución en Medicina con Sello Español: Desenmascarado un Nuevo Culpable del Infarto.