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Will RELION5 make 40kDa protein structures routine? We shall see very soon! 🙂

This is going to rock the boat even further! Already thinking about how to best use it !

When deciphering protein dynamics, why not use information we already have? Like the physical constraints of an atomic model. Looking forward to giving it a go!

Harsh Bansia will discuss temperature as an important variable in RyR #CryoEM experiments at #BPS2024 today at 5PM! Platform: Cryo-EM: From Atoms to Brains Looking forward to it!

30 Essays to Make You Love Biology Day 1. "I should have loved biology" by James Somers. "It was only in college, when I read Douglas Hofstadter’s Gödel, Escher, Bach, that I came to understand cells as recursively self-modifying programs."

SRC appears to have two binding sites on beta-arrestin. Intriguing isn't it? biorxiv.org/content/10.110… #CryoEM #Biophysics #GPCR

The FDA-approved drug Dantrolene binding site on the giant ion channel RyR1 is an ADP/ATP sensor. Isn't that cool?

Wow! Digitized scent! This sounds amazing... sorry, smells!

These AFM movies are so great!

Our lab's next read, for Thanksgiving week-end. :-)

This is a really fun paper. The authors build a mathematical model to explain how the tulip breaking virus, or TBV, creates a stripe pattern on tulip petals. The writing is elegant, and the paper combines history, mathematics, and lots of other good stuff. Recommend.

A landmark day for pain research! The FDA approved suzetrigine, a NaV1.8 blocker representing the first new class of pain drugs to be approved in over 20 years. science.org/content/articl… #painresearch #suzetrigine #paintherapeutics MargolisLab

Dantrolene inhibition of ryanodine receptor 1 carrying the severe malignant hyperthermia mutation Y522S visualized by cryo-EM dlvr.it/THvRXk

Petition to Reverse the NIH Indirect Cost Cap (NOT-OD-25-068) - Sign the Petition! The U.S. is the global leader in biomedical research, but these funding caps will dismantle decades of progress, weakening our scientific infrastructure. chng.it/9hHqTmnTm4 via Change.org

Love the post! And the science!

Discovery of a new class of natural antibiotics with a new mode of action to address antimicrobial resistance, a major unmet need McMaster University nature nature.com/articles/s4158…

Sweet!

I wrote an essay about the types of writing that I don't think AIs can easily replace. Thank you very much to Ruxandra Teslo 🧬, owl, eryney marrogi and others for speaking to me for this one. TL;DR: Double down on original reporting, missing context, and deep reflections.

We've been working on this resource for months: A VISUAL GUIDE TO GENOME EDITORS. Learn how tools like Cas9, Cas13, prime editors, and Bridge editors work - with diagrams! We hope this becomes a valuable resource for the biology community and students.

'water is transparent only within a very narrow band of the electromagnetic spectrum, so living organisms evolved sensitivity to that band, and that's what we now call "visible light". ' (found via HN)