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The innate #immune system relies on a two-step process directed by two intracellular protein families to prime, then kill melanoma #cancer cells. A new study in mouse and human cells by Lars M. Koenig and Universität München, @LMU_Uniklinikum scientists: fcld.ly/o7gv9n3

Great fun to work with Daniel Böhmer, our wonderful collaborators and the whole team on mechanisms of RNA-induced tumor cell death, now out Science Immunology #RNA, #apoptosis immunology.sciencemag.org/content/6/61/e…

#everycell is an #immunecell. Thrilled to share our latest work Immunity: activation in #platelets of the transcription factor NFAT dictates #hemostasis, #neutrophil #NETosis & #inflammation. Translational implication for #sepsis & platelet dysfunctions authors.elsevier.com/a/1eNDV3qNrUmS…

#EveryCellIsAnImmuneCell!💥Thrilled💥for our new paper Cell with Achille Broggi! We show that, during #IBD, type III #interferons delay gut repair by inducing #pyroptosis in intestinal epithelial cells via #gasdermin C upon ZBP1 activation! 1/n authors.elsevier.com/a/1k2OAL7PXqSL5

Excited to share our new research in Cell! Achille Broggi Ivan Zanoni 📢 IFN-λ senses Z-form nucleic acids during gut injury, triggering cell death & impacting epithelial regeneration. Key insights for gut health and potential therapies! FCYI kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F%2…

Imagine the gut as a highway—when damaged, certain signals can delay repairs, causing traffic jams affecting our health. Ivan Zanoni Kautilya Kumar Jena Achille Broggi Jose Ordovas-Montanes Daniel Böhmer Benedetta Sposito CIML Harvard Medical School Boston Children's Cell sciencedirect.com/science/articl…

And finally (probably) for today, my choice this week in Science Magazine Ivan Zanoni 10.1016/j.cell.2024.10.010