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the next 4 years are going to be an opportunity for a kind of muscular philanthropy that demonstrates what philanthropic $ can do when governments default on their duty to produce public goods. i hope other foundations rise to the challenge & don't treat it as business as usual.

There's got to be a better way than this GPT-4o "Great for most questions" GPT-4o mini "Faster for most questions" GPT-4o with scheduled tasks (BETA) "Ask ChatGPT to follow up later" o1 "Uses advanced reasoning" o3-mini "Fast at advanced reasoning" o3-mini-high "Great at coding

my p(doom) just dropped

1. Don’t be an asshole 2. Don’t work with assholes 3. Don’t write book chapters

This is a real photo captured through my telescope of the moon. Completely unedited/unprocessed. See anything strange?

AI fooling students into not learning fundamentals only to become easily replaceable by AI is the real x-risk

Too many people take biomedical innovation for granted.

NEW 🧵: Is human intelligence starting to decline? Recent results from major international tests show that the average person’s capacity to process information, use reasoning and solve novel problems has been falling since around the mid 2010s. What should we make of this?

I was talking about someone abt the different cultures in tech vs biotech. Tech seems much more optimistic abt the possibility for change/ doing things in a new way. Arc Institute was financed by a tech CEO. All the progress stuff w/

📢 new preprint alert: So so excited to share our analysis on the impact of common and rare variants on single-cell gene expression in blood, using WGS and scRNA-seq data from nearly 2,000 individuals and 5.4m cells as part of TenK10K phase 1 🧬medrxiv.org/content/10.110… 🧵👇 (1/n)

1/10 Why has U.S. productivity growth slowed down despite record R&D spending and more researchers than ever? We explore a surprising answer: incumbents are hiring researchers not to innovate—but to block competition.

What protects individuals from developing blood cancers? Thrilled to share my work in Vijay Sankaran lab, describing inherited resilience protecting blood stem cells from clonal hematopoiesis by modifying RNA regulation. 🧵👇(1/n) biorxiv.org/content/10.110…

For economists, the tariff spectacle currently coming out of the White House econ team is akin to watching NASA being taken over by astrologers and repurposing the International Space Station to charge magic healing crystals with moonbeams.

4 billion ghibli users

Peer review fuels a billion-dollar publishing industry. Reviewers go unpaid, authors pay to publish, and the public face paywalls. If we’re serious about reforming science, this broken system is another good place to start.

Rather than breaking NIH, Elon Musk, do the world a favor and break Elsevier.

Here is how NOT to respond when science is under existential threat

I worry that most of the focus on "AI for science" is getting it backwards. Try to do great science and build awesome technology. Build AI tools when it would be useful. Setting out to do "AI for science" will lead to all sorts of lamplight effects and square peg round holes.

Our work on widespread recessive effects on common diseases in a British South Asian cohort is now published in AJHG! Check out our summary thread here cell.com/ajhg/fulltext/…

🚨 THE TECHNO-INDUSTRIAL POLICY PLAYBOOK Is the United States still the world’s leading techno-industrial power? The answer is no longer obvious — and that should worry us. To restore our lead, we need to act. A new joint project from IFP Foundation for American Innovation 🇺🇸🚀 American Compass and