This mind-blowing research in nature shows that machine learning can effectively guide enzyme optimization and help create enzymes that degrade all kinds of plastic waste in record time 🤯nature.com/articles/s4158…

🦇 Some moths have evolved to produce ultrasound capable of jamming bat sonar pnas.org/doi/full/10.10…

Congratulations to Jennifer Brennan for her new paper in PLOS Comp Biol journals.plos.org/ploscompbiol/a… In this collaboration with the Kevin Jamieson lab, we show how to easily find synergies among many drugs. Synergies among combinations of up to 8 antibiotics were rare for 𝐸. 𝑐𝑜𝑙𝑖.

Very cool work on a conundrum in evolution: How to cross between fitness peaks? Many fitness landscapes have paths between peaks that circumvent valleys: nature.com/articles/s4155…

Balancing Trade-Offs Imposed by Growth Media and Mass Spectrometry for Bacterial Exometabolomics AppEnvMicro journal from Erik Wright journals.asm.org/doi/10.1128/ae… journals.asm.org/doi/10.1128/ae…

Clever method for getting rid of the thermocycler in PCR: nature.com/articles/s4146…

Excited this collaboration with Hensley Lab and Drew Weissman is out. Cool work in broad flu mRNA vaccines. Work on ferrets from my lab was done by Valerie Le Sage

We need a plan D (for Data!) nature.com/articles/s4159…

Happy to see Travis' work in our lab out in print. An important read if you are doing #microbiome studies. bmcmicrobiol.biomedcentral.com/articles/10.11…

So proud of my lab for this new publication in a completely different area of research for us! bmcpublichealth.biomedcentral.com/articles/10.11… And especially proud of this creative infographic created by our newest lab member!! wrightlabscience.com/index.html

Clusterize is now published in Nature Communications. nature.com/articles/s4146… Clustering large numbers of sequences accurately in linear time via relatedness sorting. Check out the accuracy relative to MMseqs, CD-HIT, etc.!

It turns out a lot of pseudogenes are actually genes. See our new publication in BMC Genomics. bmcgenomics.biomedcentral.com/articles/10.11… The extent of this problem in public genome databases is mind blowing! Congratulations to Nick in our lab for figuring this out.

The Wright Lab has a new website! I think it's the coolest lab website ever, but don't trust me: wrightlabscience.com Many thanks to Monica in our lab for catching us up to 2024! 😎

DECIPHER v3 released yesterday with lots of new features! Time to update: bioconductor.org/packages/relea…

Congrats to Sam for his publication reviewing the intersection of EHR mining, machine learning, and antibiotic resistance! Journal of Infectious Diseases doi.org/10.1093/infdis…

Years of effort culminating into an excellent paper by Sam Blechman from our lab: journals.plos.org/plospathogens/… tl;dr MRSA infections are commonly treated with the antibiotic vancomycin. Yet MRSA almost never gains resistance. Now we known why vancomycin is so durable against MRSA.

Protein structure search is becoming evermore popular. But I've always wondered whether some structure matches arise from convergent evolution. Now we know the answer – a resounding yes! This has major implications for the use of protein structure search. academic.oup.com/gbe/article/17…

Congratulations to Aidan in our lab on the publication of his tool EvoWeaver: nature.com/articles/s4146… tl;dr Partial biochemical pathways derived from genome information alone.