🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Today at the Melbourne Brain Symposium, presenting our multi-omics approach to characterize the molecular diversity of the myeloid lineage. @mincle & the Well's lab are working towards identifying novel myeloid transcripts and proteins that explain macrophage diversity (1/2).

Incredible depth & clarity of mouse brain & mouse brain tumor tissue using Akoya Biosciences Phenocycler-Fusion 2.0 combining barcoded antibody labeling & AI-assisted cell-immune-tissue phenotyping. CHECK POSTER @ #sfn2023 #research UniMelb MDHS #GBM #glioblastoma #neuroscience #cancer

#Glioblastoma initiation visualized using Akoya Biosciences Phenocycler 2.0 showing transition of neural #stemcells into #GBM cells. H&E image published in doi: 10.1093/neuonc/noy068. Using multiplex-IHC we can now see cell-molecular changes occurring during GBM development UniMelb MDHS

Our review on how a master transcriptional regulator of brain function & immunity, CREB, is co-opted to support brain tumour development UniMelb MDHS Doherty Institute Laura Cook Marija Dinevska Samuel Widodo #glioblastoma #brain #TME #immunosuppression doi.org/10.1016/j.bbi.…

Overjoyed to have graduated last week! Many thanks to Theo Mantamadiotis @BrainCancerLab, Stan Stylli & Samuel Widodo for your support throughout the years. UniMelb MDHS

2023: Marija Dinevska's PhD completion🎉; papers showed #ECM traps immune cells in #GBM & #BrainMets: thnx Samuel Widodo, Dr Stylli & the Matrix: @TCox_Lab! Looking forward to 2024 & leveraging these discoveries to enhance brain cancer therapy UniMelb MDHS Doherty Institute Akoya Biosciences

MBSANZ ECR Paper of the Year! Congratulations Marija Dinevska ! Our paper shows that immune cells preferentially localize to ECM-rich regions in brain tumors. We are investigating ways to activate anti-tumor immunity by mobilizing these immune cells Doherty Institute UniMelb MDHS

Thank you MBSANZ 🦋 @MBSANZ.bsky.social for recognising our work where we discovered that immune cells are trapped in the ECM of metastatic brain tumours. It has been great working alongside Theo Mantamadiotis @BrainCancerLab & Samuel Widodo!

Mouse brain pre (L) & post clearing (R) + spatial mIHC - we'll be able to precisely map key tumor components: Samuel Widodo Marija Dinevska RaihanahP Keast Lab. Thanks for pioneering work - ClearT2 CLARITY iDISCO et al., especially work by Ali Max Erturk #GBM #braintumors UniMelb MDHS

Amazing image produced using QuPath software by Theo Mantamadiotis @BrainCancerLab. The image showcases a blood vessel surrounded by various immune cells, including T-cells, B-cells, macrophages, and collagen. This image was captured from a #wholeslide image of human #glioblastoma, generated

Back at #lornecancer! Highlight was Michelle Monje🎗️ 🟦 's neuro-glioma talk! photo with fabulous researchers Samuel Widodo Marija Dinevska Miguel A. Berrocal Rubio checkout SW's poster #215 'Transcriptional reprogramming of tumour associated macrophages in glioblastoma'

Tumor perivascular niche? In #glioblastoma the perivascular niche has collagen, lymphocytes, macrophages - all trapped infiltrating immune cells. Using spatial mIHC we investigate how #ECM & secreted factors regulate tumor immunity #GBM Doherty Institute UniMelb MDHS Akoya Biosciences

Don't miss the Akoya Biosciences spatial biology session Doherty Institute on novel approaches investigating mechanisms in #Immunology #infection #BrainCancer & application of novel experimental & computational tools for #spatial in #organoids #pathology #cellsignalling #GBM UniMelb MDHS

Congratulations on your completion seminar Samuel Widodo! So exciting to see all your hard work come together 🎉🎉👏👏

We share our review discussing several key studies investigating the immunosuppressive tumour microenvironment, with a focus on brain cancer​ doi.org/10.1016/j.immu… Marija Dinevska Theo Mantamadiotis @BrainCancerLab

Following several presentations on how we use #spatialbiology to investigate the #immunology of #braincancer - also see our recent review on this topic shorturl.at/7pwV1 Samuel Widodo Marija Dinevska Marianna Rapsomaniki University of Melbourne Doherty Institute

Carcinogenesis: shorturl.at/6pvy6 Mice with targeted Pi3k-Pten mutations develop tumors resembling an aggressive form of sex cord stromal tumors. We describe the cell-of-origin, complex histopathology & using #spatialbiology, map immune cell infiltration of this rare cancer

Our latest publication in Science Advances is officially out! Here, we target the NPY/NPY1R signalling axis to lessen metastatic burden of mutant p53-dependent #PancreaticCancer 🔬👩🏼‍🔬 Check it out here: science.org/doi/10.1126/sc… Garvan Institute of Medical Research Invasion and Metastasis Lab