
DKFZ Epigenetics
@dkfzepigenetics
The Division of Epigenetics at the German Cancer Research Center. Pursuing research on cancer epigenetics, epitranscriptomics, ...and marbled crayfish.
ID: 3385823152
http://www.dkfz.de/epigenetics 21-07-2015 11:59:11
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DNA (de)methylation in embryonic stem cells controls CTCF-dependent chromatin boundaries [Laura Wiehle Graeme Thorn Güenter Raddatz Chris Clarkson DKFZ Epigenetics Karsten Rippe Achim Breiling Teif Lab] genome.cshlp.org/content/early/… 5hmC loss > nuc gain > CTCF loss > 5mC spreading > gene↓
![Gene Regulation (@generegulation) on Twitter photo DNA (de)methylation in embryonic stem cells controls CTCF-dependent chromatin boundaries [Laura Wiehle <a href="/geejaytee/">Graeme Thorn</a> Güenter Raddatz <a href="/chrsclrksn/">Chris Clarkson</a> <a href="/dkfzEpigenetics/">DKFZ Epigenetics</a> <a href="/KarstenRippe/">Karsten Rippe</a> Achim Breiling <a href="/TeifLab/">Teif Lab</a>] genome.cshlp.org/content/early/…
5hmC loss > nuc gain > CTCF loss > 5mC spreading > gene↓ DNA (de)methylation in embryonic stem cells controls CTCF-dependent chromatin boundaries [Laura Wiehle <a href="/geejaytee/">Graeme Thorn</a> Güenter Raddatz <a href="/chrsclrksn/">Chris Clarkson</a> <a href="/dkfzEpigenetics/">DKFZ Epigenetics</a> <a href="/KarstenRippe/">Karsten Rippe</a> Achim Breiling <a href="/TeifLab/">Teif Lab</a>] genome.cshlp.org/content/early/…
5hmC loss > nuc gain > CTCF loss > 5mC spreading > gene↓](https://pbs.twimg.com/media/D3UMIwXWkAA7NW2.png)



The New England Biolabs APOBEC-based enzymatic methylation protocol (EM-seq) is out! We see more even coverage across CpG islands & greater detection of CpG sites vs. WGBS; data coming soon from the U.S. FDA NY Genome Center #SEQC2 #EpiQC study w/ Genome in a Bottle samples neb.com/products/e7120…



How a Chinese Scientist Broke the Rules to Create the First Gene-Edited Babies via The Wall Street Journal #CRISPR buff.ly/2VtOeDQ


Challenging dogma, metastasis of #cancer occurs early: lineage of driver mutations via exome sequencing shows early seeding in > 80% of colon cancer patients nature.com/articles/s4158… by Christina Curtis Zheng Hu Stanford Medicine and collaborators Nature Genetics




Please RT: come join our group and learn wet and dry bench techniques, equip yourself for an independent research career, collaborative project with Tuuli Lappalainen #epigenetics nature.com/naturecareers/…

Nature Reviews Molecular Cell Biology proudly presents Focus on #Methylation in biology with 5 cutting-edge Reviews + commentary showcasing the latest understanding of the mechanisms and roles of methylation in animals and of its clinical relevance go.nature.com/2mmfHq1 ALL Reviews are FREE for 1 month!

#Methylation Focus issue Nature Reviews Molecular Cell Biology: Comment by Frank Lyko DKFZ Epigenetics on the importance of non-histone protein methylation in cancer therapy go.nature.com/2NviZ7H

Game changing: EMBO Press The Company of Biologists eLife - the journal PLOS bioRxiv and others offer Review Commons: post preprint, preprints get peer-reviewed, then journal reach decision. This pooled submission accelerates publishing and reduces re-review. reviewcommons.org