#IntelAtCNE

We investigated whether known allosteric inhibitors binding to a pocket adjacent to helix αD could be combined with ATP mimetic moieties. Read more about this structure-based design strategy that led to highly selective CK2 inhibitors 🔽 sciencedirect.com/science/articl…

Happy Skynet self awareness day!

So cool.

New paper from the group describing UniChromCD for time-resolved CD-MS data, especially with fancy demultiplexing strategies! Great work James "Skippy" Sanders and team! pubs.acs.org/doi/full/10.10… As always, the software is open-source and free

This has a link to a detailed analysis of higher education trends in Canada.

If you want to see what a comprehensive computational analysis of SH2 domain structure and dynamics in an oncoprotein looks like, with a little HDX thrown in on the side, then this here Sarah Rauscher paper is for you!

Ever wondered how serine octomers form to dominate spectra during ESI? Vida (Vida Alinezhad) and Kirsty (Kirsty Yuen Ki Ng) explain it all in the Konermann Lab's newest paper! We've got experiments *and* MD simulations in here so there's something for everyone! pubs.acs.org/doi/10.1021/ja…

I am pleased to see this paper on a GPCR using HDX-MS to be published today - great collaboration with OMass Therapeutics OMass Therapeutics: rdcu.be/dXlOI

I shall be there :) ... ...

🏆 Jianhong Wu, Sergey Krylov and Derek Wilson York University win a Synergy Award for Innovation in recognition of their innovative partnership with Sanofi. ▶️ tinyurl.com/y5ze66an

🏆 Jianhong Wu, Sergey Krylov and Derek Wilson York University reçoivent un Prix Synergie pour l’innovation pour leur partenariat de recherche avec Sanofi. ▶️ tinyurl.com/2s833e8m

🏆 This evening, NSERC celebrated 18 of Canada’s leading scientists and engineers, alongside 13 industry partners for their extraordinary achievements and contributions to research and training across various fields. Congratulations to all!

Mass spec friends. I have journeyed to where the *skies are blue* and found there an MS community that is large and growing quickly... And all without an algorithm that seems to want me to become an extremist who, in the wise words of Juice WRLD "hates the other side".