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Deadline Reminder Feb. 28 for Abstract, Early Fee, Award Application. Complete yours today to the 17th Int'l Conference on #ComplementTherapeutics held in #Sissi, #Crete, #Greece from May 10-15, 2025 aegeanconferences.org/src/App/confer…

Looking forward to joining #EULAR2025 #Barcelona to discuss the latest developments in #complementbiology and #therapeutics and their implications in health, disease and therapy. Many thanks to the organizers and session chairs for this invitation!

Back to the fundamentals...although I am afraid it might be too late government.se/articles/2024/…

Zymogen activation is a ubiquitous strategy for regulating enzyme activity. In our Journal of Biological Chemistry paper led by Duan, we show that blocking this fundamental process is used to inhibit the first proteolytic event of the classical #complement pathway 👇 doi.org/10.1016/j.jbc.…

Program Available: 17th Int'l Conference on #ComplementTherapeutics from May 10-15, #Sissi #Crete #Greece aegeanconferences.org/src/App/pages/…

The infinite beauty of finely regulated biology from a neutrophil's perspective...with the helping hand of #complementbiology! The recent study by Hsu et al. sciencedirect.com/science/articl… nicely placed in context by Lai Guan NG and Immanuel Kwok in this preview sciencedirect.com/science/articl…

Excited to share our review: Complement and the hallmarks of cancer - hot off the press in Seminars in Immunology! Everything you ever wanted to know about #complementbiology and #cancer but never sared ask is here👇 sciencedirect.com/science/articl…

Our News & Views article with Dimitris Mastellos discussing two recent Nature studies that report #granzymeK-mediated #complement activation in pathological contexts of CD8+ #Tcell-driven tissue #inflammation is now out in Nature Immunology nature.com/articles/s4159…

You can read our article here: rdcu.be/egmX8

Program Updated: 17th Int'l Conference on #Complement #Therapeutics held at the #KalimeraKriti Conference Center from May 10-15 in #Sissi #Crete #Greece aegeanconferences.org/src/App/sessio… Dimitris Mastellos Lubka Roumenina John D. Lambris, Ph.D.

Myeloid lineage C3 induces reactive gliosis and neuronal stress during CNS inflammation | Nature Communications nature.com/articles/s4146…

Pleased to share our newly published paper entitled: "Clinical C3 Inhibition With AMY-101 Reveals Novel Insights Into IL-8–Driven Inflammation in COVID-19" onlinelibrary.wiley.com/doi/10.1111/im… This work, which was done a few years back, investigated the effects of AMY-101 in treating severe

Congratulations to all the trainee awardees! Great Work! Great Science! 17th Int’l Conference on #Complement Therapeutics.

nature.com/articles/s4146…

1/n We profile a broad set of C3aR/C5aR1 agonists on the human/mouse receptors, and uncover some very interesting pharmacology and functional specialization. For example, C5a-d-Arg, the naturally-encoded version of C5a, acts as a robust G-protein-biased agonist at C5aR1!

Save the Date: The 18th Int'l Conference on #Complement #Therapeutics will be held from May 27 - June 1, 2026 in #Sissi #Crete #Greece at the #KalimeraKriti Conference Center aegeanconferences.org/src/App/confer… #ComplementTherapeutics

New kind of efferocytosis? Cell entrapment! nature.com/articles/s4141… Normally, macrophages engulf dying, apoptotic cells, e.g. neutrophils - process known as efferocytosis. But if neutrophils were infected with Porphyromonas gingivalis, most common bad oral bacteria, they are

Opposing roles of microglial and macrophagic C3ar1 signaling in stress-induced synaptic and behavioral changes | Molecular Psychiatry nature.com/articles/s4138…