Javier Puente (@docjavip) 's Twitter Profile
Javier Puente

@docjavip

Medical oncologist. Clinical researcher focused in GU tumors. Associate Professor UCM. Hospital Clinico San Carlos Madrid, Spain

ID: 1030110686

calendar_today23-12-2012 08:00:23

5,5K Tweet

3,3K Followers

909 Following

Juan Gómez Rivas (@jgomezrivas) 's Twitter Profile Photo

🎯Prostate-Specific Membrane Antigen Positron Emission Tomography (PSMA-PET) in Initial Staging of Prostate Cancer Patients: The Beginning of a New Era 📍 Published in @Medicina_MDPI 🔗 doi.org/10.3390/medici… pubmed.ncbi.nlm.nih.gov/40428882/ In this comprehensive review, we explore how

🎯Prostate-Specific Membrane Antigen Positron Emission Tomography (PSMA-PET) in Initial Staging of Prostate Cancer Patients: The Beginning of a New Era
📍 Published in @Medicina_MDPI
🔗 doi.org/10.3390/medici…

pubmed.ncbi.nlm.nih.gov/40428882/

In this comprehensive review, we explore how
OncoAlert (@oncoalert) 's Twitter Profile Photo

Colleagues at #ASCO25 Join us for the GUARD Symposium🇪🇸 featuring interactive workshops where experts collaboratively discuss real-world genitourinary cancer cases. REGISTER👉 events.tacticsmd.net/guard-internat… ⭐️FREE VIRTUAL Admission for LMIC's & LATAM Colleagues⭐️ This meeting

Tom Powles (@tompowles1) 's Twitter Profile Photo

1/2 ctDNA data for durvalumab+NAC in MIBC from NIAGARA #ASCO25. 57%,22%,9% of pts are ctDNA +ve at baseline/post NAC/post surgery. Poor outcomes for cDNA+ve occur at each time point (HR 0.4,0.3,0.1 respectively). Chemo cleared the ctDNA in most pts & was ⬆️13% with durvalumab

1/2 ctDNA data for durvalumab+NAC in MIBC from NIAGARA #ASCO25.  57%,22%,9% of pts are ctDNA +ve at baseline/post NAC/post surgery. Poor outcomes for cDNA+ve occur at each time point (HR 0.4,0.3,0.1 respectively). Chemo cleared the ctDNA  in most pts & was ⬆️13% with durvalumab
Tom Powles (@tompowles1) 's Twitter Profile Photo

2/2 ctDNA+ status post chemo was associated with ⬇️⬇️ likelihood of pCR at surgery. ~30% of ctDNA-ves at baseline relapsed vs 65% of +ves. Baseline status did not define pts that benefited from durva. ctDNA-ve pts post surgery(90%) also appeared to benefit from durva. #ASCO25

2/2 ctDNA+ status post chemo was associated with ⬇️⬇️ likelihood of pCR at surgery. ~30% of ctDNA-ves at baseline relapsed vs 65% of +ves.  Baseline status  did not define pts that benefited from durva. ctDNA-ve pts post surgery(90%) also appeared to benefit from durva. #ASCO25
Tom Powles (@tompowles1) 's Twitter Profile Photo

3/3 The ctDNA biomarker is not perfect (-ves still relapse post surgery) & there was no 3rd arm in NIAGARA with neoadjuvant D+NAC alone. Therefore ctDNA & pCR cannot determine the importance of adjuvant durva. A 3rd arm needed 1500 pts which seemed too many back in 2016 #ASCO25

Félix Guerrero-Ramos (@drfelixguerrero) 's Twitter Profile Photo

🤩Privileged to be co-author in this paper on the CREST trial published at Nature Medicine with Tom Powles Matt Galsky Joan Palou Redorta Evanguelos Xylinas Alberto Briganti among others 🙌🏼Thrilled to be part of an eventual paradigm shift in #NMIBC after 50 years 👣This is only the

🤩Privileged to be co-author in this paper on the CREST trial published at <a href="/NatureMedicine/">Nature Medicine</a> with <a href="/tompowles1/">Tom Powles</a> <a href="/MattGalsky/">Matt Galsky</a> <a href="/joanfundi/">Joan Palou Redorta</a> <a href="/evanguelosx/">Evanguelos Xylinas</a> <a href="/Albert0Briganti/">Alberto Briganti</a> among others

🙌🏼Thrilled to be part of an eventual paradigm shift in #NMIBC after 50 years

👣This is only the
Dr. Bosch-Barrera (@boschbarrera) 's Twitter Profile Photo

Brutales resultados del impacto de la hora de administración de la inmunoterapia en estudio randomizado. Pocos fármacos han demostrado datos tan contundentes. Debemos reconsiderar administrar la inmuno antes de las 15.00 en todos los pacientes, excepto fuera un ensayo clínico.

Brutales resultados del impacto de la hora de administración de la inmunoterapia en estudio randomizado. Pocos fármacos han demostrado datos tan contundentes. Debemos reconsiderar administrar la inmuno antes de las 15.00 en todos los pacientes, excepto fuera un ensayo clínico.
Alessandro Rametta (@alerametta) 's Twitter Profile Photo

Just back from #ASCO25, where I joined an ecancer roundtable on recent updates in renal cell carcinoma. Great to exchange views with highly experienced colleagues in the field. 🎥 Video here: player.vimeo.com/video/10898609… Guillermo de Velasco Michael Serzan, MD Javier Puente #GUcancer #RenalCancer

Michael Serzan, MD (@mikeserzanmd) 's Twitter Profile Photo

🤔 Still thinking about the fantastic #KidneyCancer program from #ASCO25? 🎙️Join international panel of experts Alessandro Rametta 🇮🇹, Guillermo de Velasco 🇪🇸, Javier Puente 🇪🇸 as we discuss how impactful RCC data influences practice today and research tomorrow! 🔗 shorturl.at/yXAZr 👥

GUARD Consortium (@guardconsortium) 's Twitter Profile Photo

🚨 ¡Recordatorio para jóvenes adjuntos! El 25 de junio tienes una cita con el GUARD Mentorship Meeting: una jornada pensada para inspirarte y motivarte desde el primer minuto. 🗓 Consulta el programa e inscríbete aquí 👉 guardconsortium.org/actividad/jorn…

TransworldHealth (@transworldedit) 's Twitter Profile Photo

🚨Disponible el 3r Episodio de la 1ª. Ed. #TooMoreUrotelio #CáncerUrotelial ¿Un punto de inflexión en NMIBC agresivo? Javier Puente y Félix Guerrero-Ramos repasan los últimos avances: 🔹Nuevos datos (Estudio CREST) 🔹BCG + sasanlimab, ¿para quién y cómo manejar toxicidad?  🔹Claves para

🚨Disponible el 3r Episodio de la 1ª. Ed. #TooMoreUrotelio #CáncerUrotelial ¿Un punto de inflexión en NMIBC agresivo?

<a href="/docjavip/">Javier Puente</a> y <a href="/DrFelixGuerrero/">Félix Guerrero-Ramos</a> repasan los últimos avances:
🔹Nuevos datos (Estudio CREST)
🔹BCG + sasanlimab, ¿para quién y cómo manejar toxicidad? 
🔹Claves para
OncoAlert (@oncoalert) 's Twitter Profile Photo

Join us for the GUARD Symposium🇪🇸 featuring interactive workshops where experts collaboratively discuss real-world genitourinary cancer cases. REGISTER👉 events.tacticsmd.net/guard-internat… ⭐️FREE VIRTUAL Admission for LMIC's & LATAM Colleagues⭐️ Here is our Colleague Dr. Felipe Couñago PhD🇪🇸 with

GUARD Consortium (@guardconsortium) 's Twitter Profile Photo

¡Gracias a todos por el éxito del Mentorship Meeting! Y en especial a Pedro C Barata, MD MSc FACP por su apoyo y su implicación. Seguro que muchos futuros proyectos de GUARD Consortium salen de esta reunión. ¡Os esperamos mañana en el GUARD International Symposium!

¡Gracias a todos por el éxito del Mentorship Meeting! Y en especial a <a href="/PBarataMD/">Pedro C Barata, MD MSc FACP</a> por su apoyo y su implicación. Seguro que muchos futuros proyectos de <a href="/GuardConsortium/">GUARD Consortium</a> salen de esta reunión. ¡Os esperamos mañana en el GUARD International Symposium!
Dra. María Natalia Gandur Quiroga (@nataliagandur) 's Twitter Profile Photo

🌟🔵 Redefining metastatic hormone-sensitive prostate cancer Javier Puente OncoAlert #GUARDSymposium2025 🔹 Timing & burden define prognosis in mHSPC 🔹 Drug selection = disease + patient + regimen factors 🔹 Triplet therapy: 94% support in high-volume, fit patients 🔹 APCCC vote:

🌟🔵 Redefining metastatic hormone-sensitive prostate cancer
<a href="/docjavip/">Javier Puente</a> <a href="/OncoAlert/">OncoAlert</a> #GUARDSymposium2025

🔹 Timing &amp; burden define prognosis in mHSPC
🔹 Drug selection = disease + patient + regimen factors
🔹 Triplet therapy: 94% support in high-volume, fit patients
🔹 APCCC vote:
Tom Powles (@tompowles1) 's Twitter Profile Photo

FGFR inhibition in FGFR3 altered UC doesn’t get the attention it deserves #GUARDSymposium2025 Its data platinum refractory UC is similar to EV. It’s used in late disease. Sadly there are no R3s 1st line or combo studies. The survey below shows enthusiasm post EVP OncoAlert

FGFR inhibition in FGFR3 altered UC doesn’t get the attention it deserves  #GUARDSymposium2025
Its data platinum refractory UC is similar to EV. It’s used in late disease. Sadly there are no R3s 1st line or combo studies. The survey below shows enthusiasm post EVP <a href="/OncoAlert/">OncoAlert</a>
Tom Powles (@tompowles1) 's Twitter Profile Photo

With the final analysis of the last of the 1st line metastatic clear cell RCC trials combination trials it’s still fair to say ‘pick one and use it well’. #GUARDSymposium2025 Ipi/nivo is less good at getting initial control but has less long term toxicity. Brian Rini, MD OncoAlert

With the final analysis of the last of the 1st line metastatic clear cell RCC trials combination trials it’s still fair to say ‘pick one and use it well’. #GUARDSymposium2025 Ipi/nivo is less good at getting initial control but has less long term toxicity. <a href="/brian_rini/">Brian Rini, MD</a> <a href="/OncoAlert/">OncoAlert</a>
Óscar Rodríguez Faba (@rodriguezfaba) 's Twitter Profile Photo

🚨Quedan 10 días para la II Edición de nuestro masterclass en cáncer de vejiga . ➡️Link para inscripción online y presencial: eira.meetingpharma.com/projects/iimee…

🚨Quedan 10 días para la II Edición de nuestro masterclass en cáncer de vejiga .
➡️Link para inscripción online y presencial:

eira.meetingpharma.com/projects/iimee…
Tom Powles (@tompowles1) 's Twitter Profile Photo

Gem/cis/durvalumab is approved in the EU for muscle invasive bladder cancer (NIAGARA study). It’s the only immune therapy study in the adjuvant or neoadjuvant setting with significant OS. ⬆️ pCR and EFS support this appr OncoAlert Annals of Oncology astrazeneca.com/media-centre/p…

Gem/cis/durvalumab is approved in the EU for muscle invasive bladder cancer (NIAGARA study). It’s the only immune therapy study in the adjuvant or neoadjuvant setting with significant OS. ⬆️ pCR and EFS support this appr <a href="/OncoAlert/">OncoAlert</a> <a href="/Annals_Oncology/">Annals of Oncology</a> astrazeneca.com/media-centre/p…