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Had cases -typically COVID like -fever. Pulmonary infiltrates elevated  CRP & D dimer.Fever. resolves in couple of days without antibiotics.Raised D dimer & CRP persist. RT PCR consistently negative. Are we dealing with a different variant?Raj Rajnarayanan Michael Michael Mina

Sarilumab for Relapse of Polymyalgia Rheumatica during Glucocorticoid Taper | NEJM nejm.org/doi/full/10.10… Is tocilizumab expected to be inferior?It has lower cost!

Colleagues from #Mumbai ! What is the latest on #Mumps over there?

Obesity began skyrocketing in the 1980s. Genes didn't change. People didn't all of a sudden become lazy. If anything, their was a heavier focus on physical activity than before. What did change? Chemicals and ultra-processed foods. ➡️High fructose corn syrup replaced sugar

Preclinical proof of principle for orally delivered Th17 antagonist miniproteins: Cell cell.com/cell/fulltext/… Heralding a new paradigm in biologicals?Will they reach the low resource countries who can not afford expensive biologicals?

Sacubitril/valsartan alleviates sepsis-induced myocardial injury in ra... sciencedirect.com/science/articl… In #sepsis one needs to look at entire organ system rather than any isolated organ liAny thoughts on what may be the net effect of this agent in sepsis?Anand Swaminathan MD MPH 🏳️‍🌈🇺🇦 Haney Mallemat

Muscarinic drugs breathe new life into schizophrenia pipeline nature.com/articles/d4157… While all are focussed on KARXT,which other currently available muscarinic agents have true potential in this sphere?

Evaluation of the effect of melatonin on patients with COVID-19 admitt... sciencedirect.com/science/articl… #melatonin dose too less. For #COVID you need much higher dose( minimum 30 mg )Used it in many critical patients in delta wave.No adverse effects except drowsiness

Have been informed that a family is being harassed for raising consumer concerns, this corporate bullying needs to stop.

Safety and Preliminary Efficacy of Transcutaneous Auricular Vagus Nerv... sciencedirect.com/science/articl… .Exciting new way prospect in treating arthritis! Tuhina Neogi, MD, PhD

Bedaquiline Monotherapy for Multibacillary Leprosy | New England Journal of Medicine nejm.org/doi/full/10.10… While good proof of concept,should we as clinicians be adopting monotherapy for a disease like this?

#PLOSONE dx.plos.org/10.1371/journa… Many times where one may have used steroids to tide over before DMARDS or biologicals set in, I have often used colchicine! Obviates need for NSAIDS too. Safer option. Worthy of larger trials. Also may reduce risk of associated ASCVD

doi.org/10.1007/s00210… Cilostazole works well in asthma as also COVID!I have used in both conditions with good results.Only issue is that it sometimes causes headache

Gut feelings on short-chain fatty acids to regulate respiratory health: Trends in Endocrinology & Metabolism cell.com/trends/endocri… As a doctor, I advise all to take psyllium daily-Simplest strategy to raise SCFA!

AI-designed proteins tackle century-old problem — making snake antivenoms nature.com/articles/d4158… India needs something like this urgently.Kudos to researchers! Take the program forward in India! Soumya Swaminathan

Metformin on Time to Sustained Recovery in Adults with COVID-19: The ACTIV-6 Randomized Clinical Trial medrxiv.org/content/10.110… Metformin given during acute COVID reduces subsequent incidence of long COVID but as this paper shows there is not much impact on acute symptoms

Evaluation of the safety and efficacy of isotretinoin in treatment of ... sciencedirect.com/science/articl… Any thoughts?Would you use it in your next COVID patient?