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Interesting paper looking at the direct and indirect effects of polygenic score for BMI on age at onset of type 2 diabetes in South Asians vs Europeans. BMI completely (100%) explained the association between BMI PGS and T2D risk in Europeans, whereas in South Asians, it

This a really exciting leap forward for genomic sequence to activity gene regulation models. It is a genuine improvement over pretty much all SOTA models spanning a wide range of regulatory, transcriptional and post-transcriptional processes. 1/

A must-read for anyone interested in human B lymphocytes, their physiology and pathology !

$INMB raised money today with full knowledge of the Alzheimer’s study data, per a source familiar with the transaction.

The unfolding drama of $INMB is hilarious! Another Cassava in the making?

Just realizing that "TTAM" in TTAM Research Institute, a non-profit founded by Anne Wojcicki, stands for Twenty Three And Me. Lol

A comprehensive fine-mapping of bipolar disorder GWAS signals by Maria Koromina et al. in Nature Neuroscience Great work with beautiful visualizations! nature.com/articles/s4159…

Transplanting dopaminergic neurons-enriched fetal midbrain into adult brains for the treatment of Parkinson's disease. The transplant didn't benefit clinically, but it blows my mind that it's possible to do with safely without major adverse events. Ref: Vivian Tabar. A trial of

Nice systematic analysis of gene convergence between common and rare variant GWAS discoveries. Not often we see common and rare variant studies implicating the same set of genes for a trait. This convergence is rare particularly for traits under strong selection like early

Continuous glucose monitoring (CGM) after intake of different types of food (n= 55 participants). Look at the rice spike! Rice is one of the major factors that drive diabetes risk in South Asians. Ref: Wu et al. Individual variations in glycemic responses to carbohydrates and

Alzheimer's disease (AD) risk at various polygenic score (PGS) percentiles compared to median group (40-60%). In addition to APOE, other risk variants as well contribute significantly to AD risk, independent of APOE (but clearly APOE is the single most important risk factor in

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Our new paper on ancient DNA to address the spread of Uralic languages now out in @nature (we started working on this in 2018). Many interesting results, including a sample from ~16k years ago Yakutia that can be modeled as an unadmixed Native American. nature.com/articles/s4158…

Despite Alector's failed Alzheimer's trial targeting TREM2, companies haven't given up on TREM2, which is a genetically validated target for Alzheimer's. Below is a list of TREM2-targeting therapeutics currently in development From a recent correspondence by Colonna and

A fifth natural short sleeper (NSS) variant (N783Y) was identified in a gene called SIK3. N783Y reduces the normal catalytic activity measured as phosphorylation of HDAC4/5. Human finding is supported by a mouse model that partially recapitulates the NSS phenotype.

Me vibe coding in the weekend

This is super cool! Looks like a tremendous resource for biologists who'd want to leverage the power of AI to accelerate their workflows.