We report today that the structurally complex PAMP LPS can be broken down to a simple pattern that is detected by the innate immune receptor caspase-11. This pattern is a lipid containing a negative charged headgroup + acyl chain ≥14 carbons. science.org/doi/10.1126/sc…

The future of ground-breaking medical research in Victoria could be under threat, without a funding boost from the State Government. New modelling has revealed 9 of the state's leading institutes are at risk of going broke within 4 years | Burnet Institute Samantha Butler

I know $60 million is an unfathomably large amount of money, BUT for every $1 invested into medical research over $4 is returned to the economy Tell me, is there any other industry that provides a +300% return on investment AND delivers life-saving/changing discoveries?

I am excited to share that Michelle's (Hui Wen) PhD work on microbial subversion of innate immune and cell death pathways is now online! Congrats Michelle Yeap and all co-authors! 🥳 embopress.org/doi/full/10.10…

Curved light-sheet microscopy nature.com/articles/s4156…

Inflammatory signalling must eventually be turned off (e.g. by feedback inhibition) to prevent chronic inflammation. We didn't know how #inflammasomes turn off their signalling in vivo ... until now! (🧵: 1/3) shorturl.at/8lWxW

Excited to share our latest work on how microRNA length variants can be leveraged as disease biomarkers. Congratulations to Alex McAllan for all her work on this! cell.com/molecular-ther…

🔊 🗓️ SAVE THE DATE ASI Innate Immunity SIG and Australian Inflammation Centres as well as Australasian Cell Death Society jointly host a symposium on 10-11 Nov at the University of Adelaide. More details to come. #ASImmunology #innateimmunity #inflammation #celldeath

For MyD88 lovers... Out today! The first article out of Elba del Val's superb PhD thesis at Complutense. A small step for one woman, a big step for our research on yeast-based SynBio models to understand human innate immune signaling pathways! link.springer.com/10.1007/s00018…

2 WEEKS TO GO! Abstract submissions for #ImmuMon2025 close in just TWO WEEKS! Don’t miss your chance to share your latest immunology research with researchers across Monash University. Abstract Deadline: 15th August Submit now: immumon.com/registration-a…

Delighted to share that our study with BioAge NLRP3 inhibitors is now online Journal of Experimental Medicine ! Together with Institute of Structural Biology Bonn Benedicte Py and Alex Weber, immunologist researcher in Tübingen we characterise BAL-0028 and BAL-0598. Excited to see the new NLRP3 biology they will reveal!

Original report on the regulators of TLR4 endocytosis and its importance in TRIF-IFN signaling. cell.com/fulltext/S0092… Ivan Zanoni Harvard Medical School Harvard Micro

😊🎉Super excited to see our collab work on #inflammation #inhibitors led by Rajendra Karki Seoul National University & Chirag Patel Technology Innovation Institute being featured on the #cover of #Cell Chem Biol Cell Chemical Biology & highlighted at #Nature Reviews Drug Discovery Nature Reviews Drug Discovery 1/2 John Curtin School of Medical Research, ANU ourANU

Excited to announce the latest research published by our lab, which is led by Dinesh Subedi Dinesh Subedi and is out today in Nature Microbiology Nature Microbiology nature.com/articles/s4156…

meta-PAMPs: A new class of immunostimulatory molecules that control the ability of bacterial factors to operate as PAMPs. Jordan Jastrab reveals that wall teichoic acid (WTA) is a key regulator of inflammasomes and interferons during infection. biorxiv.org/content/10.110…

Glad that our paper is officially out Cell. BRD4 condensate functions as a pH sensor to tune inflammatory response in macrophage. cell.com/cell/fulltext/… earlier post: x.com/XuZhouLab/stat… and could-have-been cover by my student&artist Cathleen Krabak Harvard Medical School

In my opinion, this is the most important aging-related paper of the year! It identifies a critical protein that could eventually extend lifespan by many years. Not surprisingly, it involves DNA repair and regulation of the immune response. Below is a breakdown of the key points

Very excited to share the latest work from our lab, which was published today in Nature! nature.com/articles/s4158… PhD graduate and now post-doc Sofia Dahlman, along with co-senior author Sam Forster from The Hudson, and lab members Dinesh Subedi

Today, leading medical researchers from across the nation are stepping into Parliament, joining my call for the government to release the funds being withheld from the Medical Research Future Fund. We must fund medical research properly. With the Trump administration slashing

Join me in supporting the Release the Medical Research Future Fund Campaign aamri.org.au/mrff/