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Check out our new paper describing rAcrVIA1: an RNA anti-CRISPR that mimics guide RNAs to inhibit Cas13. Very fun project with stellar UW undergrad Victoria Hayes and collaboration with Ning Jia's group! science.org/doi/10.1126/sc…

Excited to share our last collab paper, now out in print Science Magazine!🎉 We reveal how dITP synthesis activates a SIR2 NADase effector to block phage infection! 🛡️🧬 science.org/doi/10.1126/sc…

Excited to share our latest on the Type II Thoeris system! In collaboration with the Sorek and Kranzusch labs, we identify His-ADPR as a signaling molecule. Huge thanks to all involved—amazing teamwork! nature.com/articles/s4158…

Beyond cool.

A prophage-encoded sRNA limits lytic phage infection of adherent-invasive E. coli biorxiv.org/content/10.110… #biorxiv_micrbio

🚨New paper! A prophage-encoded sRNA limits lytic phage infection in adherent-invasive E. coli. Huge thanks to members of Round Lab, Duerkop Lab, Wiedenheft Lab, and phage legend Sherwood Casjens. doi.org/10.1101/2025.0…

Hidden in plain sight: Bacterial genomes reveal thousands of lytic phages with therapeutic potential biorxiv.org/content/10.110…

Very excited with how this came together. What a great team!

We performed a dedicated search of anti-CRISPR proteins targeting the model E. coli Type IE CRISPR-Cas system and revealed AcrIE9 as a potent inhibitor and the most widespread anti-CRISPR protein in enteric bacteria. biorxiv.org/content/10.110…

1/10 Today in Science Magazine in collaboration with liugroup we report the development of a laboratory-evolved CRISPR-associated transposase (evoCAST) that supports therapeutically relevant levels of RNA-programmable gene insertion in human cells. drive.google.com/file/d/1I-UbCR…

Autocycler: long-read consensus assembly for bacterial genomes biorxiv.org/content/10.110…

Our review on CRISPR-Associated Transposons and uses in genome editing is out now Trends in Genetics Right time after the seminal paper drive.google.com/file/d/1I-UbCR… by Sternberg Lab and David R. Liu labs in Science Magazine Have a look at our paper here 👇 authors.elsevier.com/a/1l7FNcQbJF91W

Our latest story is now online nature! We discovered a phage defense system that deploys kilobase-long DNA homopolymers to protect against viral infection. Congratulations to all authors, and to the Wiedenheft Lab for a fun and fruitful collaboration! nature.com/articles/s4158…

New pre-print(s) from the Sternberg Lab in collaboration with Leifu Chang! We uncover an unprecedented molecular mechanism of CRISPR-Cas12f-like proteins, which drive RNA-guided transcription independently of canonical promoter motifs. Full story here: tinyurl.com/mr3fd493

Latest BREX story from the lab - turns out there is a nuclease after all! Congrats to Jenny Readshaw and the whole team, including wonderful collabs Barry Stoddard, Brett Kaiser and Darren Smith. Nucleic Acids Res New England Biolabs Durham BioSciences academic.oup.com/nar/article/53…

So happy to share my work José R Penadés lab 🤩 We investigated the efficiency of HGT mechanisms in S. aureus🧬, finding that LT is the most efficient one, and that strains defective in immune systems🛡️act as gateways for inter-clonal complex HGT🔀 biorxiv.org/content/10.110…

Prophages block cell surface receptors to preserve their viral progeny | Nature nature.com/articles/s4158…

Is anyone routinely using plasmidsaurus for lytic, tailed, dsDNA phage sequencing? How much DNA are you sending?

Temperate phages enhance host fitness via RNA-guided flagellar remodeling | bioRxiv biorxiv.org/content/10.110…