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Understanding the aging hypothalamus, one cell at a time @KHajdarovic, Doudou Yu & Webb Lab @ The Buck Institute sciencedirect.com/science/articl… Trends in Neurosciences

'Understanding the aging hypothalamus, one cell at a time' Kaitlyn Hajdarovic @KHajdarovic, Doudou Yu Doudou Yu & Ashley E. Webb Webb Lab @ The Buck Institute cell.com/trends/neurosc…

Check our our latest review on the aging hypothalamus! We discuss recent advances made possible by the use of single cell 'omics approaches and highlight outstanding questions in the field. Well done @KHajdarovic Doudou Yu! Brown Center on the Biology of Aging Carney Institute for Brain Science cell.com/trends/neurosc…

Can we build 'aging clocks' in different cell types to measure the impact of aging and 'rejuvenation'? ⏲️ Massive congrats to Matt Buckley and Eric Sun!🍾🎉🙌 rdcu.be/c1TPK Nature Aging Great collaboration with #IrvWeissman Tony Wyss-Coray Peggy Goodell Thomas Rando!

May the force be with us today! Our First ML/AI manuscript on predicting neuronal age from single cell RNA-seq datasets is submitted! Congrats Doudou Yu CCMB at Brown @KHajdarovic Also, in case you're interested...average lifespan of a wookiee: 400 years!!!

So excited to see my review with Webb Lab @ The Buck Institute and the Fallon lab is the most read paper from StemCellReports !! 🤯🤩 I’m very proud of our work in understanding #neurogenesis in #aging and #Alzheimers 🧠

We are recruiting 1-2 postdocs to work on mechanisms of brain aging and neurodegeneration! ✨Join us Buck Institute ✨

CellBiAge: Improved single-cell age classification using data binarization dlvr.it/SzX2C3

Thrilled to see our latest work out in Cell Reports! Spearheaded by Doudou Yu and in collaboration with ML expert Ritambhara Singh (Brown U). We developed a new ML pipeline to classify cellular age in scRNA-seq datasets from the brain. Buck Institute cell.com/cell-reports/f…

Congratulations to Buck students Kelsey Babcock and Francesco Neri for their award-winning poster presentations at #BAAM2023! 👏👏👏

Incredibly excited to share our paper on the impact of partial reprogramming on neurogenic niches of the old brain (in mice)!! Massive congratulations to first-author Lucy Xu and all the authors!! 🌟🙌🍾 nature.com/articles/s4358…

So proud of Angelina Holcom, Ph.D. for winning a poster prize for her work on metabolic regulation of neurogenesis at the Bay Area Aging Meeting! 😎 Buck Institute

Excited to announce the inaugural AIMBA (AI Meets Biology of Aging) 2024 meeting on May 22, 2023, 9-2pm PT, organized by University of Washington Nathan Shock Centers ! Featuring four keynote speakers: Profs Maria Brbic, Anne Brunet, Vadim Gladyshev, James Zou. Check it out! sites.google.com/cs.washington.…

Beyond thrilled to share 3 papers on the killifish from our lab and fantastic collaborators!! 🐟🙌 Two on protein aggregates during aging – with Jarosz Lab! cell.com/developmental-… cell.com/cell-reports/f… One on evolution of 'suspended animation'! cell.com/cell/fulltext/…

🎉 Thrilled to share our latest method, IRIS, now published in Nature Methods！IRIS is a robust statistical and computational method designed to decode the spatial organization of tissues. It efficiently detects biologically interpretable spatial domains across multi-samples.

What causes Alzheimer’s disease? Scientists are searching for the answer. It’s likely a combination of brain changes, genes, and factors related to health, the environment, and lifestyle. Learn more: go.nia.nih.gov/3WIVrhB #NIAAlzheimers

Can we use CRISPR screens to identify genes that drive neural stem cell aging? Super excited to see this work published nature! Huge congrats to Tyson @ruetz_tyson, Angie Pogson, Chloe Kashiwagi, and all authors! Great collaboration with Michael C Bassik! nature.com/articles/s4158…

Thrilled to share our paper online nature (on my birthday)! We've identified a new population of LepR neurons (BNC2) in the hypothalamus ARC that acutely suppresses appetite by directly inhibiting AGRP neurons, decoding the missing LepR GABAergic neurons. nature.com/articles/s4158…

I’m pleased to announce the publication of our single-nucleus atlas of adult neurons from wild-type and long-lived, better performing insulin receptor (daf-2) mutants. DOI: 10.1016/j.xgen.2024.100720 - see the blue place for thread cell.com/cell-genomics/…

🎆4 years in the making! Thrilled to share the 1st spatial single cell aging clock⏰ nature nature.com/articles/s4158… We use #AI + spatial transcriptomics to discover what makes some cells age faster/slower in the brain🧠 Led by Eric Sun; awesome collaboration w/ Brunet Lab 🧵