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❤️🫘Cardio Kidney Metabolic syndrome kireportscommunity.org/post/ckm-syndr… KIReports

Obesity-related glomerulopathy: How it happens and future perspectives onlinelibrary.wiley.com/doi/10.1111/dm… Our review led by Lee-Ling Lim and Jian-Wen Samuel Lee-Boey

Furosemide versus torsemide: May the highest dose win! Authors glean insights from the TRANSFORM-HF trial. bit.ly/KN1704-08 Sam Kant #ASNKidneyNews #ASNJASN

SGLT-2i in Advanced CKD – Still Beneficial! (From Systematic Review & Meta-Analysis of 10 RCTs, Apr 2024) Study Focus: Can SGLT-2 inhibitors help patients with eGFR <30 ml/min/1.73m²? Key Findings: ✅ Kidney protection persists even in advanced CKD: ‣ RR 0.79 for kidney

C5b9uPR is emerging as a significant biomarker for FSGS progression, reflecting the complex interplay between complement activation, inflammation, and kidney injury. bit.ly/KID0787 #ASNKidney360

🌟Webinar recording available! Watch 👀 Joint IPNA Ped Nephrology -IPTA Webinar: “The state of the art on immunosuppressive regimens in paediatric kidney transplantation” 🗣️Stephen Marks, Sharon Teo View here 👉 vimeo.com/1075316143/8c8… #medtwitter #pediatrics

TMA involving blood vessels 🔹Onion-skin type intimal fibrosis 🔹Mucointimal edema 🔹Endothelial cell enlargement 🔹Fragmented RBCs 🔹Fibrin thrombi & fibrin in intima DD: *Malignant HTN *Scleroderma *Other causes of TMA (e.g., aHUS) #renalpath #pathtwitter

Complements and kidneys

🫘Alport Syndrome Decoded 🧬Missense: Misfolded collagen→ ER stress→ podocyte death Vs 🧬Truncating: No collagen→ weak GBM→ mesangial filopodia invade! ET-1, DDR1, integrins→ fibrosis & inflammation🤕 🔗 doi.org/10.1681/ASN.00… #Nephrology #AlportSyndrome #MedTwitter

Mecanismos de nefro protección , sitios de acción y drogas . Disponible en Circulation

#AKI in Acute on Chronic liver failure🥩: perfect storm 🌪️ Mechanisms fueling injury & strategies to fight back From gut dysbiosis to liver-kidney transplant🫘—know it all Nephrologists, this is your battlefield🤺 #Nephrology #HRS #ACLF #Hepatology 🔗doi.org/10.1111/nep.70… 🆕

🫀🫘Management heart failure with CKD NDT Hans-Joachim Anders academic.oup.com/ndt/article/38…

Intravenous albumin is generally safe for most patients. However, its potential harms may be unknown. Given safety and cost concerns, authors of a recent #Perspective recommend that for most patients, use of intravenous albumin should adhere to ICTMG recommendations.

Today is #IgANAwarenessDay! KDIGO is joining clinicians, patients, and researchers worldwide in raising awareness of IgA Nephropathy (#IgAN). Check out KDIGO IgAN resources below, and stay tuned for the KDIGO 2025 IgAN Guideline--coming this fall! Key Messages in IgAN:

Lupus nephritis B cell depletion

Acidosis

The new World Health Organization (WHO)'s World health statistics report shows that global life expectancy fell by 1.8 years —the largest drop in recent history — reversing a decade of health gains: bit.ly/437wz4w Behind every data point is a person—a child who didn’t reach their fifth birthday,

Secondary TMAs

😦Limitations of Creatinine/Urine output criteria for identifying AKI thelancet.com/journals/lance… The Lancet

Why Do Patients Discontinue Peritoneal Dialysis (PD)? Understanding and Preventing Dropout