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interesting clinical pearl on very very commonly prescribed drug.

It was a super cool pre-print. Now it's a super cool nature paper. Really innovative work The UMAP police are coming for Fig2c/d though...

ribosomal DNA copy number variation as a potential genetic influence on CKD risk. cell.com/action/showPdf… Associates with creatinine, cystatin C, urea, microalbuminuria 'kidney failure' rather than glomerular disease or urolithiasis... what does rDNA copy number do to the kidney?

Please just let the poor patients sleep

this is a very interesting sequence-function association for the small number of enhancers that operate a large distances. Curious principle for gene regulation -

A privilege and honour to receive the Raine award and I hugely enjoyed sharing our science at #UKKW2024

More questions than answers

amazing!

Congratulations Asger This is very interesting and important work!

very useful package if you're in a multiplexed bind demultiplex.readthedocs.io/en/latest/inde…

Very cool ancient genomics

underrated tweet.

Every project is unique – like a ❄️– but after experiencing many projects it also gets pretty clear that there is pretty much a common way they unfold, once the initial idea happens:

Great collaboration between the Hughes Group and Watkins labs, reporting the first Gain of Function de novo enhancer causing Mendelian disease (ST Depression Syndrome), defining a multidisciplinary path with ML to solving non-coding clinical genetics. medrxiv.org/content/10.110…

🫠🫣

V promising approach perturb multiome - effects of tf perturbations on chromatin accessibility and expression pmc.ncbi.nlm.nih.gov/articles/PMC11…

(1/8) Excited to share our latest preprint introducing ACCESS-ATAC, a high-resolution approach to measure chromatin accessibility and transcription factor binding: biorxiv.org/content/10.110…

tantalizingly clean