I think this is the most exciting thing to happen in depression for research for at least the last decade. Pramipexole works for TRD.

Good to see solid negative findings in catatonia research. It gives you confidence that studies are being conducted well. In this study of critically ill patients from Jo Ellen Wilson's group, frailty was not associated with development of catatonia. doi.org/10.1016/j.jacl…

🕰️ What is Temporal Drift? Data that clinical prediction models face when implemented can differ from the data they were trained on, even in the same setting. This can be due to changing patients, treatments or practices The result? The model’s predictions start to go wrong.

Do you ever think about the consequences of a brain that cannot forget? Should we be rethinking the movement disorder known as dystonia and helping people to forget? A brilliant new perspective by Mark Hallett in the journal Parkinsonism and Related Disorders highlights something

New study of over 120,000 #clozapine therapeutic drug monitoring samples finds #smokers may need lower #plasma levels than nonsmokers for treatment-resistant #schizophrenia. Adverse drug reactions appear earlier in nonsmokers, particularly in women. 🔗 journals.lww.com/psychopharmaco…

The EU have reduced clozapine FBC monitoring to 3-monthly after a year. Hopefully the MHRA will follow suit. Maudsley_pharmacy were the first to trial this, and the only ones to report on safety. A huge step forward for patients, and rational science. medscape.com/viewarticle/eu…

CBD is good right? Errr maybe not... In this RCT, I gave high doses of THC 🌿 to people with schizophrenia. Pre-treatment with CBD did not reduce the effects... but doubled them! 🤯 Sometimes I'm not sure that science is for me 🤡.

A summary of where we’re at with biofluid biomarkers for parkinsonian disorders and their potential clinical value in the near future. Also looking forward to talking about this topic at Association of British Neurologists Autumn meeting in November: theabn.org/page/autumn-me…

Great to see our DTA meta-analysis on EEG in psychosis published today in Schizophrenia research. Please see the thread below outlining the main findings and the full paper: sciencedirect.com/science/articl…. Great collaboration between Oxford Psychiatry and UCL Psychiatry