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What is the role and the sensitivity and specificity of a urinalysis for the diagnosis of urinary tract infections? 🧪🧫🔬

Urinary nitrite testing introduces diagnostic confusion without adding value with regard to the decision to treat False +ve: asymptomatic bacteriuria, contamination False -ve: UTI due to non nitrate–reducing bacteria (e.g. Enterococcus, Acinetobacter species) H/t Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟

Urinary catheters should only be used when needed and removed as soon as they are no longer necessary. Here are some complications of urinary catheters and mechanisms for prevention doi.org/10.1001/jamasu…

Estimated per-act probability of acquiring HIV from an infected source, by exposure act dx.doi.org/10.15585/mmwr.…

Figure showing evidence for detection of 27 viruses in the semen, their viability in the semen, sexual transmission, and detection in other parts of the male reproductive tract doi.org/10.1016/j.lanm…

In moderate to low quality observational data, cefazolin was non-inferior for mortality and potentially superior for safety as compared to anti-staphylococcal penicillins overall and across most individual comparisons doi.org/10.1016/j.cmi.…

Meta-analysis on mNGS for infectious meningoencephalitis ➡️ 23 studies, n = 1660 ➡️Pooled sensitivity = 0.70 and specificity = 0.93 (for TB: 0.67 and 0.97) Further research is needed: ➡️ for which patients? ➡️ at what point in the diagnostic process? doi.org/10.1093/ofid/o…

Trilled to be part of this landmark #RCT for #MASLD in #PLWH published in #LancetHIV☺️☺️ Big congratulations to our amazing #InfectiousDisease team under the leadership of #DrGraceLui 🥰🥰 Full text: authors.elsevier.com/a/1l3J88MsVohm…

🆕💫The MEFIER Score - A Risk Score to Stratify Infective Endocarditis in Patients with Enterococcus faecalis bacteremia based on an 11-year territory-wide cohort AUROC of 0.79 (95%CI 0.72-0.88), and a NPV of 0.98 (95%CI 0.97-0.99) #idxposts #IEWiki academic.oup.com/ofid/advance-a…

Suggested strategies for treatment of resistant/refractory CMV disease for transplant recipients doi.org/10.1016/j.ijan…

Hematology thin smears (HS) perform equally to parasitology thick and thin blood smears (PS) for the diagnosis of Plasmodium and Babesia infections in a low prevalence setting 93.3% sensitivity 99.8% specificity 97.7% PPV 99.4% NPV 100% concordance with PS (for new cases)

Radiologic algorithmic approach to immunocompromised patients without HIV with masses and nodules doi.org/10.1016/j.ches…

🆕🔥Systematic review and consensus guidelines for dose adjustments The Lancet Infectious Diseases with many 🌟 Jason Roberts Amit Pai The pharmacokinetics of antibiotics in patients with obesity Thanks Ignacio uman EnJoy #IDXposts thelancet.com/journals/lanin…

A large cohort study with target trial emulation including >500k patients found no benefit associated with antibiotic treatment for 🏥 patients with nonsevere COVID-19 Routine use of antibiotics for these patients should be avoided given the known harms doi.org/10.1001/jamane…

Words matter. It’s time to retire the term oral “step-down.” It implies inferiority of the oral route—and doesn’t align with stewardship principles. Terms like IV to oral switch or oral transition better promote optimal antimicrobial stewardship. What terms do you use—and why?

In this study that included 42067 adults in 🇺🇸, long-acting lipoglycopeptides (laLGPs) were effective as step-down treatment of serious gram +ve bacterial infections, offering comparable outcomes (readmission/ED visit/90d inpatient☠️) vs SOC antibiotics doi.org/10.1001/jamane…

Suggested investigation of suspected immunosuppression* *Also: recurrent deep abscesses, chronic diarrhoea with weight loss, recurring infections, infection requiring prolonged antibiotic therapy, persistent rash (particularly without recent antibiotic use).

Pathophysiology and risk factors of ocular candidiasis Systemic treatment: 1st line = fluconazole or voriconazole (Posa: poor penetration Isavu: lack data) Lipo ampho B +/- flucytosine if resistant or refractory Echinocandins: poor penetration doi.org/10.1016/j.cmi.…

Antimicrobial resistance, antimicrobial tolerance and heteroresistance in Pseudomonas aeruginosa doi.org/10.1038/s41579…

Among 100 patients with persistent MSSA bacteraemia who were treated with ertapenem combination therapy, those with hypoalbuminemia (<2.5g/dL) had a significantly longer time to negative blood cultures. doi.org/10.1093/jac/dk…