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5 suggestions for the FDA, CDC, and ARPA-H. (Well, actually 8, but the final 3 are cheating.) This post gets a little detailed, but the orienting prompt is: what policy changes would make medical research more impactful? Hope you enjoy: blog.jacobtrefethen.com/policy-ideas-p…

GiveWell probably aren't saving the lives of the same children each year...Phew!...really cool exploration of this as an issue by Adam Salisbury here: givewell.org/how-we-work/ou…

The new Chancellor could boost UK GDP by 4.4% with this one simple trick... In our latest briefing, Lucia Coulter Lee Crawfurd & Tammy Tan highlight the economic and social cost of childhood lead poisoning, a hidden epidemic which costs the UK 4.4% of annual GDP.

Wow, that went well...Twice-Yearly Lenacapavir or Daily F/TAF for HIV Prevention in Cisgender Women | New England Journal of Medicine nejm.org/doi/full/10.10…

Happy to be naive on what are good/bad aesthetics - but, after a week of Gdocs/sheets, I (still) like to watch this sometimes youtube.com/watch?v=UqJJkt…

I’ve read a lot of stuff about #mpox already that is wrong or at least confused. And it’s not that surprising. The situation is pretty complicated and confusing. I tried to disentangle a few things for News from Science here (thread to come later): science.org/content/articl…

AMC for broad-spectrum antivirals - yes please

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In 1995, treatment options for HIV were completely transformed. I made this chart with data from the NCHS, showing the impact of highly active antiretroviral therapy (HAART). It profoundly improved the survival of people with HIV & reduced the risks of passing it on to others.

A thread about how science should work, ways to cheaply save lives, peer review, and diarrhea 👇

The new EU Commission must lead the way in tackling the lead poisoning epidemic. Center for Global Development experts propose the Commission should: 🇪🇺 Pledge to end lead poisoning within the EU 💶Invest in new tech ✅Improve regulation And more: bit.ly/3XJ9JyW

"Today, USAID, UNICEF and Open Philanthropy are... launching the Partnership for a Lead-Free Future... We’ve mobilized more than $150 million — more than 10 times the current global investment each year." Launch event today 7pm UK / 2pm ET - watch at leadfreefuture.org

Today at #UNGA79, 2pm ET UNICEF & USAID are convening public and private partners to launch the Partnership for a Lead-Free Future. The Partnership will address the scourge of lead poisoning in children in low-and-middle income countries, where over 90% of the global harm

You: High-impact research ideas to help understand and mitigate the global burden of lead poisoning 👍 🤝🤝🤝🤝🤝🤝🤝 Us (@Cgdev): An RfP with up to $1 million total to get your big ideas off the ground 👇 cgdev.org/blog/wanted-yo…

🚨 Lead research grants 🚨 Please share! New Center for Global Development call for research proposals on reducing lead poisoning in the developing world. Three broad areas: 1. Sources: where is the lead coming from 2. Impacts: measuring harms from lead 3. Solutions: evaluating policy tools

GiveWell revisited its cost-effectiveness estimate of GiveDirectly unconditional cash transfers: we think they're 3-4x more CE than we'd previously estimated, & about ~30-40% as CE as our marginal funding opps. Blog: blog.givewell.org/2024/11/12/re-… Main analysis: givewell.org/international/…

1/6 Our Global Health and Wellbeing staff often use back-of-the-envelope calculations, or BOTECs, to estimate a grant’s potential impact. A 🧵 on some real-life examples from OP grantmaking:

New in the NYT: pesticides like paraquat cause >100k deaths to suicide per year, and means restriction works - following bans in China, their pesticide suicide rate fell ~60%. Props to James Snowden and GiveWell for their early work here; Open Philanthropy is proud to continue it.

The developed world has eliminated leaded fuel and lead in paint. @c_don7, Lauren Gilbert and James Hu explain that it will be surprisingly easy to do this in the developing world too, and why doing so matters. worksinprogress.co/issue/the-end-…

"Many global health problems are thorny and difficult. Lead, unusually, is not one of those. We already know how to reduce lead exposure. Rich countries have already done it." Great new Works in Progress piece by Clare Donaldson Lauren Gilbert and James Hu