Hypoxia as a therapy for Parkinson's disease! New study w/ Fumito Ichinose shows PD mice have brain hyperoxia. Chronic 11% FIO2 delays neurodegeneration and *reverses* motor symptoms. Might explain why PD can improve w/altitude (thin air) or smoking (CO). rdcu.be/ezw02

Excited to share our new preprint led by Kirandeep Deol! Genetic screens uncover mechanisms regulating FSP1 abundance in cancer. Vitamin B2 metabolism promotes FSP1 stability via FAD synth / binding, further linking nutrient metabolism to #ferroptosis. biorxiv.org/content/10.110…

Derepressing nuclear pyruvate dehydrogenase induces therapeutic cancer cell reprogramming dlvr.it/TMLRTX

Oh brother

Considering the recent “success” of OpenAI, mathematicians are safe in the LLM era.

The first and most important task in academia is to attract a nemesis - only way to guarantee you’ll be consistently read

Hey Grok, which metabolites are hard to measure by LC-MS metabolomics but their concentrations are highly needed in almost every experiment in cancer metabolism?

I was waiting for public, but grok it is lol

Human Interactome biorxiv.org/content/10.110… Protein-protein interaction prediction for the [almost] whole human proteome. One of the heuristic optimizations is accounting for protein localization to narrow down the number of possible pairs (instead of 57,000^2, which is ~3.25B)

New! Online now: Portal vein-enriched metabolites as intermediate regulators of the gut microbiome in insulin resistance dlvr.it/TMw6qV

Happy to share our new paper in nature led by staff scientist Xuejing Liu Xuejing (Jessica) Liu, MD, PhD. We report identification of a UCP1-independent pathway of brown fat thermogenesis involving ATP-consuming metabolism of BCFA in peroxisomes. #Obesity #T2D nature.com/articles/s4158… WashU Medicine Department of Medicine

Only single cell sequencing of the all these post docs will reveal why

Mapping the plasma metabolome to human health and disease in 274,241 adults go.nature.com/4mmToc0

Excited to share this new review I co-wrote with my wonderful colleagues in the Jill Roberts Institute for IBD Research Weill Cornell Medicine, led by Iliev Lab Microbiota-mediated mechanisms of mucosal immunity across the lifespan ⁦Nature Immunology⁩ nature.com/articles/s4159…

Copilot in Excel is a global financial crisis waiting to happen.

MTAP is the Phoenix of Cancer Metabolism. Cannot die.

when i write "we" in a paper, i'm referring to myself and the voices.

I suspect Mozilla in vibe coding. Constant Firefox crashes, v. 143-144 😔😔😔

New! Online now: Nutrient allocation fuels T cell-mediated immunity dlvr.it/TNhc72

RESEARCH | S Jung, Cholsoon Jang et al. (UC Irvine): The dietary fibre inulin is shown to promote fructose catabolism by the small intestinal microbiome, thereby mitigating fructose-induced hepatic steatosis 🦠🐭 nature.com/articles/s4225…