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🚨HHV-6B reactivation after haploidentical HSCT -- impact of antiviral therapy? 🔎Retrospective study in Open Forum Infectious Diseases -NO diff most outcomes for treated vs. observed patients - even in 🔼viremia‼️ - worse outcome if🧠involved Added by Neeraja Swaminathan transplantid.net/DJBHL4B4

Oral doxycycline for the treatment of ocular syphilis may be safe and effective in a selected subset of patients who completed an extended oral antibiotic regimen. ja.ma/4gmGGHP @bradspellberg

Factors Associated With Poor Clinical and Microbiologic Outcomes in Candida auris Bloodstream Infection: A Multicenter Retrospective Cohort Study bit.ly/4im63eQ

#CCRdownunder attendees, check out these findings from this year's Critical Care Reviews meeting 🧵: In critically ill adults w/ suspected sepsis, antibiotic regimens were reduced when guided by measurement of procalcitonin but not by C-reactive protein. ja.ma/49BSvrC

🆕️🌟The first study to compare diagnostic performances of (1→3)-β-D-Glucan (BDG) and Aspergillus galactomannan (GM) for the diagnosis of HIV-associated histoplasmosis #idxposts ijidonline.com/article/S1201-…

🔥 New in BSAC 👉 academic.oup.com/jac/advance-ar… “Sixty-three out of 227 (27.8%) patients experienced at least one side effect, the most common of which were hepatotoxicity (7.0%), nausea/vomiting (6.6%), and diarrhoea (6.2%). 12 (19.0%) patients with side effects underwent an

Detection of pneumococcal carriage in asymptomatic healthcare workers ✅ Just Accepted 🔗 bit.ly/40HAc1e

Treating acute cholangitis = adequate drainage + covering organisms from blood cultures Additional coverage of organisms only grown in bile results in ⬆️ antibiotic duration and 🏥 stay, but similar organ failure/mortality/re-intervention rates doi.org/10.1016/j.cmi.…

Across ~750k inpatients in 928 U.S. hospitals, starting with empiric narrow-spectrum antibiotics escalated to broad-spectrum antibiotics based on cultures was NOT associated with worse outcomes compared with empirically starting broad. academic.oup.com/cid/advance-ar…

Prophylaxis for Spontaneous Bacterial Peritonitis: Thing we do for no reason? Todd C. Lee Brad Spellberg Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 Elliot Tapper academic.oup.com/cid/advance-ar…

UTI vs "UTI" ⁉️ In this cohort of patients diagnosed with "UTI" only about 30% had symptoms consistent with infection. ED setting and patients with mental status changes are key opportunities for antibiotic stewardship. onlinelibrary.wiley.com/doi/10.1002/na…

An observational cohort study of bronchoalveolar lavage fluid galactomannan and Aspergillus culture positivity in patients requiring mechanical ventilation ✅ Just Accepted ✍️ Cathy Gao-Howard, MD MS, NM Pulmonary and Thoracic Surgery 🔗 bit.ly/3XbAonp

Potential Impact of Doxycycline Post-Exposure Prophylaxis on Tetracycline Resistance in Neisseria gonorrhoeae and Colonization with Tetracycline-Resistant Staphylococcus aureus and Group A Streptococcus ✅ Just Accepted bit.ly/43iUM9W

🆕💫MidLine_PICC RCT Midline Venous Catheter vs Peripherally Inserted Central Catheter for Intravenous Therapy #idxposts jamanetwork.com/journals/jaman…

Incidence of Breakthrough Fungal Infections in Patients with Isavuconazole Prophylaxis: A Systematic Review and Meta-Analysis ✅ Just Accepted 🔗 bit.ly/41Yjyd5

Patterns of decline in measles, mumps, and rubella neutralizing antibodies and protection levels through 10 years after a second and third dose of MMR vaccine ✅ Just Accepted 🔗 bit.ly/4jqugQy

🆕💫 Viewpoint JAMA Internal Medicine Nitrites for Urinary Tract Infection—Time to Say Goodbye? Cc Brad Spellberg #idxposts jamanetwork.com/journals/jamai…

🆕💫Nationwide retrospective cohort study Among the 471 694 eligible patients, 63.3% received 2 g/day and 36.7% received 1 g/day of ceftriaxone. Outcomes of ceftriaxone 2 g versus 1 g daily in hospitalized patients with pneumonia #idxposts academic.oup.com/jac/advance-ar…

Urinary tract infections in immunocompromised patients 🔺Treatment of ASB does NOT reduce symptomatic infections and may LEAD to resistance and adverse events. journals.lww.com/co-infectiousd…

NO ASSOCIATION BETWEEN PREPROCEDURAL FASTING AND WITNESSED PULMONARY ASPIRATION A SYSTEMATIC REVIEW AND META-ANALYSIS I want to bring to everyone's attention the publication of an article we have been working on for some time. Ever been annoyed by having cases cancelled because