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Check out Biogen at #ASHG19 career fair: we're building a strong team to leverage & move beyond genetics towards the treatment of devastating brain, muscle and eye diseases

Delighted to share our latest preprint: the largest analysis assessing the contribution of rare genetic variants to the risk of depression, based on the exomes from 320,356 UK Biobank participants medrxiv.org/content/10.110…

We're thrilled to release a manuscript on rare variant association testing on the exomes of 300k individuals in the UK Biobank medrxiv.org/content/10.110… and a browser of the results: genebass.org

Very excited that our joint FinnGen+UK Biobank coding variant #research is out with Springer Nature in nature. Rare & common disease genetics, >650k, >700 diseases, lots of cool insights. More to follow! rdcu.be/cHCMs nature.com/articles/s4158…

New preprint! We studied how rare protein-coding variants impact cognitive function & linked diseases in UK Biobank. We identified 8 large-effect cog fx genes, dosage-sensitivity for KDM5B, additivity of rare variant and polygenic risk & more (1/12) medrxiv.org/content/10.110…

Genetic associations affecting gene expression are often dependent on unknown (biological) context. In our latest preprint, we introduce PICALO: a method that identifies hidden eQTL contexts that we refer to as Principal Interaction Components (PICs). biorxiv.org/content/10.110… 1/8

New preprint led by Jamie Robinson, Tom Gaunt, Jie Zheng (Chris)! Privileged to be on the team with my Biogen colleagues Yunfeng, Denis Baird, Ellen Tsai. An efficient and robust tool for colocalisation: Pair-wise Conditional and Colocalisation (PWCoCo) biorxiv.org/content/10.110…

Our paper on rare variant associations in the UK Biobank is out in Cell Genomics today! cell.com/cell-genomics/…

1/10 Large eQTL resources enable identification of genes for which cis-eQTL effects colocalize with GWAS hits. We are happy to announce that our MetaBrain study and eQTL resource is now out at Nature Genetics (nature.com/articles/s4158…).

Here's the full graphic for risk factors over the course of lifespan (see prior tweet)

GENETICS: This is how it works. wp.me/p24AbZ-AP

Searches for "how can I move to Canada" on Google have spiked +350% in the past four hours #SuperTuesday

#marchforscience #standupforscience

#marchforscience #standupforscience

Here's what it was like at the #MarchForScience scifri.me/c01

There were so many good dogs at the #MarchforScience, we can’t pick a favorite trib.al/iPrY9Wu