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Gordie Howe and Mario Lemieux would like a word The fact that Mt. Rushmore only has four slots doesn’t mean “the Mt. Rushmore of (X)” only needs four slots (The number should be relevant to the most important figures of (X) not an arbitrary “4”)

Live shot of Adam coming back from vacation on the 21st

People tend to focus way too much on who "wins" a "debate" on one of these shows, while the best of them recognize the end goals and talk about how to get there (The best of the best even recognize the weaker parts of their theses/positions and admit/discuss them)

Congratulations Lucas Cheadle! Very well deserved!

Median age of survival for cystic fibrosis patients was 4-5 in 1954. I’m 34 in 2025. Today, some median project survival analyses say CF patients born today can expect to live to be 70+ Feels like we’re healthier now than ever before.

Implantable BCI company? Not for the faint hearted. It’s ~ 15+ years. Control your burn if early. You can’t spend to accelerate safety. (Below, “clinical” means fully implantable technology stack and company sponsored trial) Assumptions based on class 3 PMA stories and looking

40 years, last game, first star, that was awesome! Congrats Sam on an incredible career!!

It doesn’t take years to design the drug. It takes years to figure out if you were right. Could we make that faster? Yes, probably with a lot of work (and success won’t come all at once) But I’m gonna bet the immediate answer isn’t just a better algorithm…

Derek Lowe continues to be my favorite Derek* 100% agree with his points here. * Maybe favorite writer named Derek? Also he spells his name right, which gives him additional points.

"I told you yesterday, NO!" youtube.com/watch?v=jZybUK…

Richard S. Finkel, MD, director of the Center for Experimental Neurotherapeutics at St. Jude Children’s Research Hospital, has been named to TIME 100 Health, recognizing his contributions to global health in 2025.

With the caveat that I have immense respect for @USV and Fred Wilson it is not possible for me to hate a life science investment thesis more than this. (Perhaps with the exception of "Biology is just Code" although this is basically saying the same thing)

This is excellent.

Also this

This cow followed its dreams #Parksandrec #JeanRalphio

Glad to see this dialogue happening Rachel is one of the most thoughtful and insightful people in this field, and one of the voices that should definitely be heard

Bingo

Sounds like a contractual term that just about any early stage founder will be familiar with…

1/ 🧬 How to Price a Platform in Biotech Q2 M&A is ripping, Capstan just cleared $2.1B at Phase 1, and something important has changed. A new market dynamic may be emerging, where optionality matters again. Let’s break it down with math, comps, and a framework 🧵

We are so excited to get to work with the Nancy Lieberman Back to Life Center at Mount Sinai and to welcome Steven Spohn (Spawn) as our Director. Although we're starting with spinal cord injury, we are hoping that this is an idea that will rapidly expand to 1/ reports.mountsinai.org/article/rehab2…