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Head-to-head comparison of immune response, both antibody and cellular, for 4 vaccines: Moderna, Pfizer, Novavax and J&J cell.com/cell/fulltext/… Cell Prof. Shane Crotty La Jolla Institute Zeli Zhang Jose Mateus @camilahcoelho Alessandro Sette

Our new review ‘Stem-like’ precursors are the fount to sustain persistent CD8+ T cell responses” is out ⁦Nature Immunology⁩. Great team effort with Dietmar Zehn ⁦Oxenius Lab⁩ Robert Thimme ⁦TEXIMMED2- Freiburg Labs⁩ and Gustavo Almeida nature.com/articles/s4159…

It's a NEJM case report, but a groundbreaking one. For a woman with refractory pancreatic cancer, genetically engineered T cells directed towards the KRAS driver mutation achieved substantial tumor regression nejm.org/doi/full/10.10…

I earned my PhD yesterday! In person too! What a surreal feeling all around. Wildly thankful for my incredible mentors on this journey, @FertigLab Dr. Neeha Zaidi Dr. Elizabeth Jaffee and everyone who made this possible.

How do different routes of #mRNA vaccination (made by Tiba Biotech LLC) impact the differentiation and distribution of #vaccine elicited CD8 and CD4 T cell memory responses in mice? Buck O'Flanagan Masopust Vezys Lab NIAID CIVICs 👇🏼 biorxiv.org/content/10.110…

Our immune system follows circadian rhythm. A new review Science Immunology. And why getting Covid vaccines in the morning elicits a better antibody and cellular immune response science.org/doi/10.1126/sc… Christoph Scheiermann Lab

So lucky to have been able to work with Emily Davis-Marcisak, PhD an incredibly talented, creative and overall amazing scientist! I have no doubt you will continue to do incredible work. Congratulations!

Minimize the chances of missing a T cell population critical to your therapy success!💪🏼 OS-T enables #TCR #sequencing of up to #1M #cells per sample at cellular resolution. Submit your #abstract and opt-in to an opportunity to be awarded 4 free samples! omniscope.ai/abstract-submi…

Here's a neat tech, where they capture T cells based on adherence to target tumour cells in a microfluidic device: doi.org/10.1002/adhm.2… A fast assay that addresses a lot of problems from say sticky multimers, and twiddling the pressure lets you sort out high avidity binders.

ICYMI Vinod BalachandranMD Memorial Sloan Kettering Cancer Center recent adjuvant trial of an mRNA #vaccine in patients with #PancreaticCancer (a collaboration with BioNTech SE) was featured on @cnn (Dr. Sanjay Gupta).

“This grant proposal describes breeding experiments in peas. This reviewer remains unconvinced about the translational benefits. Applicant should switch to a more economically important crop like wheat. Applicant’s productivity also an issue, no paper published in last 8 years”.

Identification of Pathogenic Immune Cell Subsets Associated With Checkpoint Inhibitor-Induced Myocarditis dlvr.it/STHB7s

Beautiful to witness every kind of Evolution. This one speaks directly to my scientific heart!

The most recent paper from the lab has been published at Journal for ImmunoTherapy of Cancer. We employed single-cell mass cytometry to delineate tumor-associated and systemic immune profiles in #PancreaticCancer. jitc.bmj.com/content/10/7/e…

Cancer #immunotherapy #DataScience resource of the week: #scRNAseq & #scTCRseq atlas of 400,000‼️T cells from 316 patients of 21 cancer types, derived from tumors, adjacent normal tissue, and peripheral blood.Half of data newly sequenced, half gathered from literature. 🧵(1/4)

It’s spatial profiling day on bioRxiv! Now 10x Genomics out with a preprint on integrated single cell, spatial and in situ analysis of FFPE tissue. Very excited by the extension of these high dimensional technologies to archival samples! biorxiv.org/content/10.110…

Presenting Slide-TCR-seq: our method for measuring the transcriptomes of cells & T cell receptor (TCR) sequences in situ! This collaboration w/ Bryan Iorgulescu, Shuqiang Li, Catherine Wu, and Fei Chen Lab led to some cool findings... cell.com/immunity/fullt… 1/8

New🔥 #DataScience #Bioinformatics resource: 850,000‼️ #scRNAseq cells from 226 samples across 10 cancer types draw a map of the tumor microenvironment, in particular fibroblasts. Let’s see👇what are the main contributions of this work & what this means for #cancer #Genomics🧵

mRNA-4157/V940 is an investigational personalized #cancer #vaccine consisting of a single #mRNA coding for up to 34 neoantigens that is designed to stimulate an immune response by generating specific T cell responses based on the unique mutational signature of a patient’s #tumor.