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TP53: - Discovered 45 years ago, most cited gene all time - No therapies - 500 million people currently living will die of TP53 mutant cancers without new therapies Our Preprint: - A general strategy for TP53 missense mutant cancers (majority) with prototype small molecules

🚨 New publication alert! 🚨 Radiotherapy can both enhance & hinder tumor immune recognition. While some patients benefit from combined radiotherapy & immunotherapy, challenges remain. A recent NCI-IOTN-sitcancer-AAI Workshop identified key priorities: - Biomarker-driven

Great work by Eric presenting the results of our Metacure B2 trial cohort: SBRT plus short course ADT/ARPI in largely PSMA PET staged, post RP, metachronous CSPC. Significant number of durable PSA0 with recovered T. #ASCO25 #pcsm

Tagging the awesome Eric Bent!