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New! Online now: Spatial regulation of glucose and lipid metabolism by hepatic insulin signaling dlvr.it/TKBr1X

a mechanism by which the most common genetic cause of MASLD and MASH leads to hepatic steatosis, whereby increased WAT catecholamine sensitivity leads to increased fatty acid flux to the Liver

Prolonged fasting promotes systemic inflammation and platelet activati... sciencedirect.com/science/articl…

New content online: A modified liver enzyme with enhanced stability helps to control glycaemia bit.ly/4ip56kJ

Oral mannose supplementation is well-tolerated and commercially available at a low cost, making it an appealing therapeutic option

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Transit time assessments are frequently used and typically evaluated using gastric emptying scintigraphy, breath tests or colonic radiopaque markers, but they cannot measure contractile activity or fluid transport link.springer.com/article/10.100…

Unique reproducibility effort in Brazil focuses on common methods rather than a single field ― and prompts call for reform

This study shows that BMI ≥60 kg/m2 is not only plausible, but is increasing at a rapid rate, warranting dedicated tracking in national health surveys

challenging widespread enthusiasm for faecal microbiota transplant as a strategy to address dysbiosis

with GIPR antagonism, unlike agonism, depending on functional GLP-1R signalling.

Use of a low-potency statin for 10 years was associated with a 34% higher risk of type 2 diabetes, while use of a high-potency statin for 10 years was associated with a 72% higher risk

Given such emerging evidence, clinicians should be more aware of signs and symptoms of NAION such as blurred vision, impaired colour vision, and visual field defects in patients with a history of semaglutide use

C7* is a preadipocyte population that differentiates upon induction, despite having increased expression of muscle cell genes, with an inverse correlation between its abundance and BMI sciencedirect.com/science/articl…

The anatomical position and physiological roles of the liver suggest it is a prime candidate to serve as an interoceptive sensor of peripheral tissue and systemic energy state sciencedirect.com/science/articl…

FGF21 increases hepatic sympathetic nerve activity and lowers de novo lipogenesis cell.com/cell-metabolis…

Bariatric surgery targets the gut-brain axis via gut hormone release, nutrient sensing, and bile acid signaling sciencedirect.com/science/articl…

Most alarming was that nearly one in five of those affected left academia or science entirely

87% of diabetes and 92% of GWAS data come from populations of European ancestry, significant gaps remain in the understanding of the biological underpinnings, environmental factors, and translational implications of T2D and GDM phenotypes diabetes.emory.edu/_includes/docu…

previously unrecognized features of skeletal muscle insulin resistance that elude detection through conventional comparative approaches