This is the end of the world as we know it, if this is reproducible! The new era of functional modeling has begun. I took a transcription factor with an unknown structure and folded it with its recognition sequence embedded in longer DNA. AlphaFold3 accurately positioned the

One of the most challenging, long and frustrating studies I have ever been involved in. But also so rewarding, interesting and fascinating. 🧬👩🏻‍🔬💚 Such a joy to finally see my work out on ⁦Nature Genetics⁩. ⁦ #Epigenetics matters, this is why 👇🏻 nature.com/articles/s4158…

After a constructive set of reviews, our single-cell reporter work is OUT nature.com/articles/s4159… Check out the briefing if you want the tldr nature.com/articles/s4159… I am particularly fond of some of the new applications. Mini-update.

What is the origin of our body? Our paper Cell shows that when a human embryo is one day old and comprises just two cells, only one cell will create most of the fetus in addition to placenta, while the other cell will create placenta. cell.com/cell/fulltext/…

👇🏾Incredibly important topic - congratulations to ⁦MarineLab⁩ ⁦Nicholas McGranahan⁩ and all involved Decoding the interplay between genetic and non-genetic drivers of metastasis | Nature nature.com/articles/s4158…

New preprint up, showing how snowflake yeast overcome one of the greatest limitations on the evolution of multicellularity: diffusion. They do so by leveraging emergent biophysics to rapidly flow media through their bodies, like a sea sponge. 1/28

Our latest study presents open access RNA-seq data from cell lines from 731 people from 26 globally diverse populations, addressing a persistent ancestry bias in our field. We hope this resource enables more equitable advances in personalized medicine. nature.com/articles/s4158…

Please RT! 🧬🧬 I am looking for a #postdoc fellow to lead a new project in 3D chromatin organisation and transcriptional regulation in cancer (experimental and/or computational) at South Australian immunoGENomics Cancer Institute in Adelaide. Apply below: careers.adelaide.edu.au/cw/en/job/5146…

If you want to know how transcription factors do their job check it there! biorxiv.org/cgi/content/sh… Wonderful collaboration with the Ochiai lab Hiroshi Ochiai that led to the real time imaging of SOX2 at the Nanog locus while transcription is on in stem cells.

Beyond excited to share my main postdoctoral work. We developed a robust mouse cortical organoid system, which recapitulates in vivo tempos and cellular diversity, and applied it to identify gene expression changes across subspecies during development. shorturl.at/9w0zT

can AI do research-level mathematics? make conjectures? prove theorems? there’s a moving frontier between what can and cannot be done with LLMs. that boundary just shifted a little. this is my experience with AI proving a new theorem. 1/

Excited to share the latest work from my lab and Emily Wong led by Daniel Medina Cano Tarek Veronika Petrova. We developed a new protocol to generate mouse cortical organoids from pluripotent stem cells. Memorial Sloan Kettering Cancer Center Center for Stem Cell Biology at Sloan Kettering MSK ScienceEducation biorxiv.org/content/10.110…

In ⁦nature⁩ we use single cell multiomics, fibroblast fate tracing, and in vivo models to characterize immune fibroblast crosstalk in heart failure with ⁦Lavine Lab⁩ ⁦WashU Medicine⁩, ⁦⁦Amgen 🧪🔬🧬⁩ , and ⁦ImmunoFibHF⁩ nature.com/articles/s4158…

🚨New in nature from the Tuomas Tammela Lab: how aging suppresses tumorigenesis and stemness in the lung by promoting functional iron insufficiency in the alveolar epithelium. Interestingly, this renders aged cells resistant to ferroptosis. nature.com/articles/s4158…

Several years in the making (and aging), Xueqian Zhuang 's study on aging is out today nature. She finds, surprisingly, that aging suppresses tumorigenesis and stemness in the lung by promoting a functional iron insufficiency in the alveolar epithelium. nature.com/articles/s4158…

Our article is out in its final form. doi.org/10.7554/eLife.… D. melanogaster even-skipped enhancers control transcriptional bursting by tuning frequency and amplitude—regardless of varying TF inputs—even when mutated to express in embryonic regions not under selective pressure.

Looking forward to this meeting!

Congrats to Thomas Vierbuchen and team and to Veronika Petrova for her PhD work in developing a sensitive method for measuring single cell allelic differences Victor Chang Cardiac Research Institute UNSW cell.com/developmental-…