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CDK4/6 inhibitors transiently induce a senescence-like state in breast cancer cells, which however cannot be eliminated by senolytics - but Boshi Wang and colleagues Demarialab find that they are instead sensitive to lysosomotropic agents! ERIBA embopress.org/doi/full/10.10…

Proteogenomic analysis of evolved aneuploid cell lines & primary tumors reveals adaptive strategies for alleviating the consequences of aneuploidy in cancer – including increased expression of DNA replication and repair factors Zuzana Storchova and coworkers embopress.org/doi/full/10.10…

EMBO is on Bluesky, and we look forward to meeting you there! bsky.app/profile/embo.o…

Under the leadership of Dr. Olof Idevall-Hagren, scientists show that #IsletCell primary cilia endow #somatostatin with the ability to regulate islet cell function beyond acute suppression of hormone release. 🧪 The EMBO Journal | bit.ly/3Qh3xcL

Congratulations to Julia Vorhauser @mansfeldlab The ICR for winning the @EMBOReports poster award at #EMBOmetabolicDiseases !

Modulation of tumor inflammatory signaling and drug sensitivity by CMTM4 embopress.org/doi/full/10.10…

📢Paper Alert! 👏👏New publication out The EMBO Journal by the group of Paul Schulze-Lefert MPIPZ Cologne and colleagues at UoC and Westlake University on immune receptor engineering for plant resistance.👉bit.ly/3EGyfd2 #Engineering #plants #Immunology embopress.org/doi/full/10.10…

Identification of Poldip2 as exonuclease essential for paternal mtDNA elimination allows assessing the importance of this process for ensuring proper spermatogenesis and sperm functionality in Drosophila Hong Xu and colleagues embopress.org/doi/full/10.10…

Hansong Ma and coworkers identify POLDIP2 as a novel mitochondrial exonuclease interacting with CLPX protease and promoting elimination of paternal mtDNA during Drosophila spermatogenesis embopress.org/doi/full/10.10…

In issue 4: FAM134B isoforms control ER dynamics in myogenesis Bacterial virulence factor targets both neutrophils & complement system Special pericytes in pulmonary capillaries Cover: 1st plant spliceosome structure by Yichen Lu, Ke Liang & Xiechao Zhan embopress.org/toc/14602075/4…

Local weakening of cell-extracellular matrix adhesion triggers basal epithelial tissue folding Andrea Valencia-Expósito, María Martín-Bermudo et al embopress.org/doi/full/10.10…

Somatostatin released by pancreatic δ-cells triggers local cAMP and Ca2+ signaling in primary cilia of nearby β-cells, to modulate their function beyond acute suppression of hormone release Olof Idevall-Hagren and coworkers embopress.org/doi/full/10.10…

Greatwall kinase is key for mitotic entry in metazoans, so how can worms do without it? Pintard et al find sole canonical MAST kinase, KIN-4, assumes its role in PP2A-B55 phosphatase inhibition & coordination of cell divisions & development in C. elegans embopress.org/doi/full/10.10…

Cryo_EM shows how barley NLR immunoreceptor MLA13 binds a fungal RNase-like effector from pathogenic grass powdery mildew Aaron Lawson, Paul Schulze-Lefert et al César Plasencia.bsky.social embopress.org/doi/full/10.10…

Immediate early splicing (IES): Florian Heyd and colleagues show that phosphorylation-controlled gene expression changes upon T-cell activation also includes a rapid and transient splicing switch that controls de novo translation embopress.org/doi/full/10.10…

Synergistic & antagonistic activities of IRF8 & FOS enhancer pairs during an immune-cell fate switch Graf, Nikolaou et al show individual enhancers act as stage-dependent, dynamic safeguards during CEBPA-induced B-cell-to-macrophage transdifferentiation embopress.org/doi/full/10.10…

SIRF: Sergio Acebron @acebron and colleagues develop a new biosensor reporting on functional interactions between dsDNA sensor STING and IRF3, allowing to capture STING activation upon various triggers embopress.org/doi/full/10.10…

I'm excited to share the final version of this story published in The EMBO Journal Check it out! embopress.org/doi/full/10.10…