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Very pleased that Eric Harshfield has been promoted to senior research associate level in the Cambridge Stroke Group. Congratulations Eric and very well deserved Cam Neuroscience ⁦CambridgeCardio⁩

Delegates at the Cambridge #CADASIL meeting at #HLRI . Lots of exciting new data and great to see drug trials underway in both Far East and Europe ⁦Cadasilsupportuk⁩ ⁦Cam Neuroscience⁩ ⁦CambridgeCardio⁩

Excellent presentation by Bernard Cho at Cambridge ⁦British Heart Foundation⁩ CRE annual day showing previously thought to be rare mutations in NOTCH3, HTRA1, and COL4A1/2 are much more common than expected in the population and associate with stroke and dementia ⁦CambridgeCardio⁩

The ⁦Cambridge Stroke⁩ team have had a great time in Munich for #ESOC2023 We’ve enjoyed sharing our work and hearing about the exciting developments across all aspects of stroke care. See you for #ESOC2024 !

📚🔬 #Metabolomics analysis of UK Biobank 🇬🇧participants revealed novel risk factors for SVD, stroke, and dementia 🧠. Exciting potential for understanding diseases 🙇🏽‍♀️, predicting progression 🤕, and personalized treatments 🎯 Cambridge Stroke Neurology Journal 👉🏽 acortar.link/j9RYsH

Do CVD risk factors affect white matter hyperintensities? A new study suggests only 15% of WMH variance is explained CVD risk factors, suggesting that further research is needed. #AHAJournals Cambridge Stroke ahajrnls.org/3K6P5BG

Pleased to share our latest NMR metabolomics paper in over 118,000 UK Biobank participants! We conducted observational and Mendelian randomization analyses to examine associations with stroke, dementia, and MRI markers of SVD. Thanks to @AlzheimersSoc @CambridgeCardio Cambridge Stroke

Our review on AI/ML for dementia is online. Insights into a growing field. More deep learning is used, but we need validation and realworld data to translate for patient benefit. Massive collaborative effort from DEMON Network Imaging WG Robin Borchert doi.org/10.1002/alz.13…

🚨Delighted to share our collaborative paper on 'AI for #dementia #genetics and #omics' DEMON Network doi.org/10.1002/alz.13…

It's a pleasure to let you know that within the DEMON Network we are organising a Mendelian Randomisation Symposium at the The Alan Turing Institute. Invited speakers include Stephen Burgess, Kate Tilling and Jack Bowden ! Abstract submissions are open until 30 Sep: t.ly/LmQcK

A publication from last month using NIAGADS data 🧬 "Association of Baseline Metabolomic Profiles With Incident Stroke and #dementia and With Imaging Markers of Cerebral Small Vessel Disease" by Eric Harshfield and Hugh Markus Cambridge Stroke ncbi.nlm.nih.gov/pmc/articles/P…

From earlier this year but still pleased to see this review out doi.org/10.1002/alz.13… Brilliant authorship team from DEMON Network inc Eric Harshfield Liu Shi AmanPreet Badhwar, MSc, PhD Dr Ahmad Al-Khleifat Petra Proitsi Natasha Clarke (migrating to @clarken.bsky.social) Imre Lengyel Sarah Marzi Timothy Rittman Edina Silajdzic ..

Happy to share our editorial "Challenging Antiplatelet Therapy for Small Vessel Stroke Through Genetics." Editorial ahajournals.org/doi/10.1161/ST… Paper "Does Thrombosis Play a Causal Role in Lacunar Stroke and Cerebral Small Vessel Disease?" ahajournals.org/doi/10.1161/ST…

So pleased that the MINERVA trial results are now published in Alzheimer's & Dementia Journals - this was a significant part of my PhD work and a huge team effort to complete the recruitment and analysis (1/6): alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…

🧵ICYMI: #STROKE #OriginalResearch: Genetic variants associated with thrombosis are associated with cardioembolic and large artery stroke but not lacunar stroke, highlighting the need for novel therapies in this condition.

No significant difference found between anticoagulants and antiplatelets in early secondary prevention of stroke after cervical artery dissection, finds meta-analysis. ja.ma/4bgDJXh

🌟A Mendelian randomization study identified 13 plasma proteins linked to small vessel disease (SVD) markers, cognitive decline, dementia, and stroke. Adam Butterworth @NielsPR Zihan Sun Eric Harshfield Stephen Burgess Cambridge Stroke Cam Neuroscience @CambridgeCardio Cambridge University

#STROKE: Endothelial-platelet activation and complement-mediated regulation of inflammation play roles in #SmallVesselDisease, and identify potential therapeutic targets and pathways. #AHAJournals ahajournals.org/doi/full/10.11…

Excellent talk by Zihan Sun on her exciting work using proteomic data to show endothelial dysfunction and inflammation in cerebral #SVD and identify drug repurposing opportunities at Cambridge ⁦British Heart Foundation⁩ CRE ⁦CambridgeCardio⁩ annual meeting ⁦⁦⁦Cam Neuroscience⁩

Rui Li describing her exciting new LUMEN AI software to segment out small brain perforator arteries in cerebral #smallvesseldisease at ⁦CambridgeCardio⁩ annual meeting ⁦British Heart Foundation⁩