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Pre-print alert! 🎉 In this collaborative project we linked microglial states to lesion expansion and repair in multiple sclerosis human brain tissue, using spatial transcriptomics analysis. Thanks to everybody who contributed! Read about it here: biorxiv.org/content/10.110…

🚀 Thrilled to see our study "Spatiotemporal transcriptomic map of glial cell response in a mouse model of acute brain ischemia" published in @PNAS! Major credit to Daniel Žucha for leading this work, and a big thanks to all collaborators and funders who made this possible 🙌🧵

🚀 Excited to see Bristena Ionescu PhD project, with co-first author Alexandra Nicaise, featured on the cover of Cell Stem Cell - Cholesterol-fuelled neurotoxic senescent PMS iNSCs and its pharmacological rescue is a major leap forward! 🎉 (link cell.com/cell-stem-cell…)

🌟🧠 New Cover from the Studio! We’re excited to share our latest cover illustration on this month's Cell Stem Cell cover, showcasing two groundbreaking studies on using patient-derived brain cells and cellular reprogramming to model multiple sclerosis (MS). These studies reveal

“I hope fewer people are affected by MS in the future. That’s why I’m doing my work – to stop MS and create a better world.” 🧡 We caught up with #MSHistoryMaker and PhD student Nelson. He shares his hopes for the future of MS research 🔬 mssoc.uk/3YGUBBr

Officially a #volleyballschool. #H2P

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. Djenet Bousbaine led the charge... nature 1/55

Delighted to see this effort from the extremely talented master's students Madalena Abade and Marlene Patterer off the press today 👏👏👏 Brain organoid methodologies to explore mechanisms of disease in progressive multiple sclerosis frontiersin.org/journals/cellu…

Excited to finally have this published! Out today in Nature Communications, we show that following demyelination in a mouse model of Multiple Sclerosis, treatment of senescent microglia with senolytics leads to improved remyelination. nature.com/articles/s4146… 1/3

Excited that Phil Gross, PhD’s paper in the role of senescence in remyelination has now been published in Nature Communications! Congratulations Phil and thanks to all the lab members George Melchor Zeeba Manavi and collaborators SchaferLabUMassChan Jason Plemel Meng-meng Fu for working with us in this

Excited to share our latest (and first from the lab) preprint where we investigated the molecular mechanisms that drive Nestin-expression progenitor differentiation in the developing cerebellum. 🧠 biorxiv.org/content/10.110…

Congratulations to Cambridge University Women's Crew for winning the 79th Women's Boat Race! 👏

The 170th Boat Race goes to the Cambridge University Men's Crew! 🏆

Join us at the Nobel Symposium Multiple Sclerosis: Past, Present and Future Treatments June 5th, 2025 | Jacob Berzelius lecture hall Karolinska Institutet| Stockholm, Sweden free registration at: jirango.com/cview/web/f049…

Excited to share our new paper in J Transl Med: …nslational-medicine.biomedcentral.com/articles/10.11… ICV delivery of fetal-derived neural stem cells is safe and may slow disease in SOD1 ALS mice. A small step in a bigger fight. Grateful to all involved, and fitting timing during #ALSAwarenessMonth

Online now: Selective removal of astrocytic PERK protects against glymphatic impairment and decreases toxic aggregation of β-amyloid and tau dlvr.it/TKvcZJ

In the battle against brain disease, researchers can now rely on a new arsenal of genetic tools – The Armamentarium. Together with scientists from across the NIH BRAIN Initiative, we’ve created and published over 1000 new enhancer AAV vectors.

Online now: GADD45G operates as a pathological sensor orchestrating reactive gliosis and neurodegeneration dlvr.it/TKx5Wv

Macrophages release neuraminidase and cleaved calreticulin for programmed cell removal PNASNews pnas.org/doi/10.1073/pn…

Silencing mitochondrial gene expression in living cells | Science science.org/doi/10.1126/sc…. Wonderful that our paper is out now in Science. A big thanks to LD Cruz-Zaragoza and the team, Warscheid lab & JakobsLab .