Interested in the interplay of DNA damage, repair and features of the genome? UV mutagenesis? 🧬☀️ Or... are you hiring? 🕵️‍♀️ All good reasons to come chat with me or visit poster 118 at #EMBLCanGen !

A real moonshot project in biomedical research would be a decisive legal, regulatory and IT effort to really make data access work for researchers across the world. Less sexy, but better bang for the buck & more transformative than e.g. AI, CRISPR, ginormous sequencing projects.

❗️Our preprint “Identification of Clonal Hematopoiesis Driver Mutations through In Silico Saturation Mutagenesis” is out medrxiv.org/content/10.110… Thrilled to present this study by Santi Demajo Meseguer Joan Enric Ramis Z Ferran Muiños Miguel L. Grau Maria Andrianova abeldavidgp Nuria Lopez-Bigas in a tweetorial 👇🏽

We’re very happy to see this finally out! “Hotspot propensity across mutational processes” with Ferran Muiños abeldavidgp Nuria Lopez-Bigas bbglab IRB Barcelona Can mutational hotspots help to study the mutation rate variability at single-nucleotide resolution? --> doi.org/10.1038/s44320…

Last days to apply for the international PhD position!💻💻🧬

📢#BarcelonaBiomed Conference "#Cancer Promotion: Understanding Cancer Promotion to Inform Prevention!": Registrations now open! 👉3-5 June, 2024 📍Casa Convalescència, #Barcelona ✅Organized by Nuria Lopez-Bigas-#IRBBarcelona, Allan Balmain-UC San Francisco & Paul Brennan-IARC

Esta semana se ha publicado un estudio en Nature Medicine que confirmaría los 5 primeros casos de transmisión accidental de una patología parecida al Alzheimer. El artículo ha generado muchos titulares y requiere algunos matices. Abro hilo ⬇️

The new Ground Truths is on a very concerning NEJM prospective multicenter study today 2 big firsts: 1. Micro/nano plastics found in majority (58%) of patient carotid artery atherosclerotic plaques 2. Carried a 4.5 fold increased risk of major adverse outcomes [link in profile]

Our work on the origins of second malignancies in children is out in Cancer Discovery IRB Barcelona bbglab Institut de Recerca Sant Joan de Déu doi.org/10.1158/2159-8… 1/16

Would you believe me if I told you that a single variant in a non-coding RNA explains ~0.5% of all undiagnosed individuals with neurodevelopmental disorders (NDD) in Genomics England ??? I didn’t initially either, but here is the story of RNU4-2 🧵1/9

Our story about mutagenesis assosiated with POLD1 deficiency is published! Congratulations and great thanks to everyone involved!

"Carcinogènesi, mutagènesi i promoció; o com treure l'entrellat de la gènesi del càncer" és el títol del darrer post que he escrit, espero que el trobeu interessant. La recerca del càncer avança molt, però encara tenim moltes preguntes per respondre: shorturl.at/dtSX2

📢 Very happy to share our latest paper Identification of Clonal Hematopoiesis Driver Mutations through In Silico Saturation Mutagenesis, just published in Cancer Discovery Explore our findings here: aacrjournals.org/cancerdiscover… 🩸🧬💻

Newest Science Magazine paper from Cancer Grand Challenges Challenges PROMINENT!! They identified stem-cell gene networks associated with their stemness or proliferative states, and its potential response to chemotherapy. Cool insight 🔍 into cancer 'promotion'!!💪 science.org/doi/10.1126/sc…

The #BiomedConference is going on. Having interesting and useful discussions with other researchers during the poster session.

Today Raquel Blanco (Raquel Blanco) presented her work on "Clonal selection in the normal human bladder" at the IRB Barcelona Node Seminar session. Nice work and nice talk. Keep doing and explaining science that way Raquel👏

We are pleased to present our latest paper in Nature Genetics where we analysed #wgs data from over 10k tumours across 35 different #cancer types in the 100k Genomes Project (Genomics England) nature.com/articles/s4158… 1/

🔵New open position: we are seeking a lab technician to join our Pyrenean biodiversity research projects!🦠🧬⛰️ Perfect for early career looking for a supportive learning environment Centre for Genomic Regulation (CRG) 🔗Job offer: recruitment.crg.eu/content/jobs/p…

📣 Two ERC-funded positions are available in the lab! If you’re interested in exploring the mechanisms underlying mutation, we’d love to hear from you. ibe.upf-csic.es/work-with-us/j… RTs and shares would be greatly appreciated!

New research from #CancerGrandChallenges team PROMINENT funded by Asociación Española Contra el Cáncer, published in nature, uncover clues as to why men face a higher risk of bladder cancer and reveals that tobacco smoke acts as a promoter, not an initiator, in bladder cancer development. By