Evidence continues to emerge that CD4 T cells are important for cancer vaccines. New study in human renal cancer shows that >90% of T cells generated by cancer vaccine are CD4, not CD8. nature.com/articles/s4158…

slate.com/life/2025/02/n…

US judge blocks Trump administration from cutting NIH grants amid ongoing litigation fiercebiotech.com/biotech/us-jud…

NIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New Report forbes.com/sites/michaelt…

How did I not think of this ? So insightful. So specific. Just leverage AI.

Is that the new poverty level?

Quote of the day: “If you think research is expensive, try disease.” Mary Lasker

After 18 years as an editor at Nature Portfolio journals and Science Magazine , I am now a freelance editor. By being a step away from your work, I can take an objective view and give constructive feedback to improve papers and grant proposals. biosciedit.co.uk 1/n

Now this is cool: sciencedirect.com/science/articl…

My response to Secretary Kennedy's statements about me on Fox News today. It's time to set the record straight.

Slowly but steadily, who's really in charge of #adaptive #immune responses is emerging. Stay tuned for our take on this in #cancer. #Bcells JCI - B cells shape naïve CD8 T cell programming jci.org/articles/view/…

Online now: Transcription factor T-bet regulates the maintenance and differentiation potential of lymph node and lung effector memory B cell subsets dlvr.it/TLTcvx

"We have been living in what many rightly call a golden age of immunology. Immunologists' discoveries are redefining medicine [...] and creating mechanism-based strategies to treat or prevent these diseases." aai.org/About/Presiden…

BREAKING: We uncovered a potent immune alliance that could change how we treat solid tumors. Published in Cancer Cell , we show that Th17 cells *must* work with B cells to eliminate tumors—and keep it from coming back. 📄 cell.com/cancer-cell/fu… 🧵1/12👇Let’s walk through it:

Preprint: TCR-enriched nanoscale vesicles shed by activated T cells (ectosomes) are transferred to antigen-primed B cells, where they engage and cluster cognate pMHCII, triggering signaling and specific IgG antibody production biorxiv.org/content/10.110…

Lung metastasis and recurrence is mitigated by CAR macrophages, in-situ-generated from mRNA delivered by small extracellular vesicles Nature Communications nature.com/articles/s4146…

Engineering B cells to treat and study human disease nature.com/articles/s4158… Nature Biotechnology Richard G. James

Editorial expression of concern Cancer Cell Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis cell.com/cancer-cell/fu… investigation: "there are no authentic, original, and uncontested data to verify the results presented in the publication"

Amen!

Did anyone notice how B cells and monocytes seem to be the MAIN antigen presenting cells physically interacting with BOTH CD4 and CD8 T cell subset? 🤯