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Super excited to share that ENGRAM is out today! ENGRAM cells are programmed to write their histories into the genome, recording the intensity, duration, and order of biological events simultaneously. nature.com/articles/s4158…

1/ 🚨 Excited to share my Postdoc research with @geochurchlab at @harvadmed! Dive into our discoveries on the central dogma of biology, antibiotic resistance, #compbio designs, and #synbio. 🧬🔬 Check our paper: biorxiv.org/content/10.110…

The next generation! Congratulations Amir Brivanlou! The human mitochondrial mRNA structurome reveals mechanisms of gene expression | Science science.org/doi/10.1126/sc…

Our new paper on epigenome editing is out! We mapped which effector domains regulate transcription across genomic, cell type and DNA-binding domain contexts. Then we built new gene repressor and activator tools with improved efficiency & deliverability nature.com/articles/s4158…

Site of breast cancer metastasis is independent of single nutrient levels biorxiv.org/content/10.110… Very important work on metabolic dependencies of metastasis from the MVH Lab

Genome engineering excelled at small nucleotide changes, but large edits remained challenging. Recent innovations are changing this. We reviewed the field of structural variant engineering Nature Genetics 🧬 Juliane Weller Thomas Vanderstichele @LeopoldParts nature.com/articles/s4158…

We are happy to share our enhancer scramble story, a strategy to create hundreds of stochastic deletions, inversions, and duplications within mammalian gene regulatory regions and associate these new architectures with gene expression levels 🧵 @LeopoldParts, Pierre Murat

This pretty much settles it: we're entering the era of low-cost, on-demand binders for everything Excited to see what people build now that "inject a llama with some junk and bleed it a month later" is no longer the cutting-edge tech nature.com/articles/s4158…

Rearranging mammalian genomes with recombinases to study structural variants at scale provides insights into genome organization and dispensability. science.org/doi/10.1126/sc… and science.org/doi/10.1126/sc… #NBThighlight

I’m delighted to share our work on scrambling the human genome using prime editing, repetitive elements, and recombinases Science Magazine! Raphael Ferreira @LeopoldParts Tom Ellis, george church @SangerInstitute science.org/doi/10.1126/sc… Lots of changes from the preprint. A🧵

Out now in Science Magazine - Jonas and Raphael’s human genome Scramble paper which inadvertently also led to us making the ‘most engineered human genome ever’ (we think so - happy to hear otherwise). Check out Jonas’ thread below. ⬇️

@LeopoldParts does amazing science and it would be a great environment to join!

🚨Excited to share our latest work, now out in Nature Biotechnology ! We introduce SEED-Selection, a powerful method that enables high-efficiency enrichment of T cells edited at multiple loci in a single step 🧵👇 🔗 nature.com/articles/s4158…

What happens to bacterial genomes when they're cloned into yeast? Do they transcribe, do they get silenced, do they get packaged away from the rest of the DNA? This cool study congrats to the Koszul lab team at Pasteur for this great work science.org/doi/10.1126/sc…

Our work on nucleic acid sensing in live human cells is out 🧬⚫️🟢! Big thanks to Ahmed mahas Lisa Riedmayr george church ! Make sure to check out Ahmed's thread 👇

Cool new RNA/DNA sensor combining RT and splint ligation!

1/10 Today in Science Magazine in collaboration with liugroup we report the development of a laboratory-evolved CRISPR-associated transposase (evoCAST) that supports therapeutically relevant levels of RNA-programmable gene insertion in human cells. drive.google.com/file/d/1I-UbCR…