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🤯🤯Woaah that’s how you do a change over

The first experimentally-solved, 3D structures of the human sweetness receptor. Resolved in complex with sucralose and aspartame; but the structures were identical. Upon binding, these molecules cause the protein to *slightly* bend & trigger a signaling cascade in the cell.

After the deadline is before the next deadline

In a medical milestone, a customized base editor was developed, characterized in human and mouse cells, tested in mice, studied for safety in non-human primates, cleared by U.S. FDA for clinical trial use, manufactured as a complex with an LNP, and dosed into a baby with a severe,

Postdoc opportunity! The Comparative Genomics lab (Institute of Evolutionary Biology (IBE), UPF Barcelona) is seeking a postdoc with experience to work on environmental DNA and mammalian monitoring together with Esther Lizano ! CVs -> [email protected] #postdoc #genomics #eDNA #conservation #Barcelona

Polly Fordyce at #VariantEffect25

I'm excited to share our new preprint "Steering Generative Models with Experimental Data for Protein Fitness Optimization" (🧵1/5)! Paper: arxiv.org/abs/2505.15093 Code: github.com/jsunn-y/SGPO

See Isabelle Zane’s amazing artwork summarizing each speaker at the #VariantEffect25 - crazy how well each drawing captures the main messages so beautifully, and for such diverse talks😍! Kresten Lindorff-Larsen

The W-S lab is seeking to hire a research scientist! This person will lead wet-lab innovations in our team as we combine AI and experiments to understand and design dynamics! Thanks for sharing/RTs! jobs.wisc.edu/jobs/scientist…

Thank you, Mohammed AlQuraishi, for kicking off our new series of early-career talks! Next week, on 6/11 at 4PM ET, we will be hosting Noelia Ferruz for our second installment of this series!

Reminder that Noelia Ferruz is giving her talk today!

Gordon Conference on Plant Metabolic Engineering, in Barcelona: amazing talks this morning about using artificial intelligence and language models to annotate, or even design new proteins with enzymatic activities. Fascinating. rdcu.be/eq9yB biorxiv.org/content/10.110…

Genuinely enjoyed the session yesterday! thanks for letting me show our work :)

Metagenomic-scale analysis of the predicted protein structure universe - Combine and cluster 821 million protein structures. Merge the AlphaFold DB and ESM Metagenomic Atlas into the AFESM dataset - Perform two-step clustering: use MMseqs2 for sequence clustering to generate 187

Our new ChemRxiv preprint: AIMNet2-rxn: A #MachineLearning Potential for Generalized Reaction Modeling on a Millions-of-Pathways Scale! #compchem Collaboration with Brett Savoie group. Funded by Office of Naval Research (ONR) under #MURI program chemrxiv.org/engage/chemrxi…

novonordiskfonden.dk/en/news/new-da…

It’s never been easier to align your protein language model (pLM)! We’ve released a major update to our ProtRL repo: ✅ GRPO via Hugging Face Trainer ✅ New support for weighted DPO Built for flexible, scalable RL with HF trainer base! Check here: github.com/AI4PDLab/ProtRL

sri and I are excited to be presenting our work this Tuesday (7/1) at 4pm ET!

We have the honor to have Joanna Joanna Slusky 🫖 in town! If you’re in Barcelona and like protein design, don’t miss her talk - Joanna always delivers the most engaging talks!

Registrations to the 2025 AI for Protein Design, sponsored by EMBO, Rosetta Commons, proteinsociety, Kura Biotech and AI Proteins, being held in Puerto Varas, Chile, are now OPEN! More info, deadlines & attendee selection process: meetings.embo.org/event/25-ai-pr… #EMBOaiProteinDesign