As for your claims on linoleic acid causing diabetes, this is not supported by human RCTs or cohort data pubmed.ncbi.nlm.nih.gov/34417277/ pmc.ncbi.nlm.nih.gov/articles/PMC74… pubmed.ncbi.nlm.nih.gov/2923077/ Keep mentally masturbating over isolated biochemical pathways though. That’s what I used to do when

You obviously didn’t understand my video. I said: it’s a river. Linoleic acid flows through D6D to AA, which is constantly being released and reattached in the Lands Cycle. While detached it can be oxidized and excreted. No reason to expect high D6D to lead to high AA.

That’s what you’ve got? High D6D activity increases diabetes risk by 500% in adult humans. Of course I simplified my argument for the needs of the internet. Dietary oleic matters, LA matters, genetics matter. You’re saying we should feed the enzyme that is causal in diabetes?

Here’s a challenge to you. Find a better predictor of diabetes onset in “healthy” adult human beings than Delta 6 Desaturase activity. I bet you can’t.

The same transcription factors that increase LA -> AA also increase AA->oxylipins. So yes, I ALSO expect that declining AA is BAD. When ALL n6 fats start declining you are becoming diabetic because the n6 fats fuel the diabetes spiral.

There are 1000 studies, showing that D6D activity causes everything bad. Most of them are from Northern Europe or Spain, for whatever reason. The fuel for D6D is linoleic acid. The easiest way to increase throughput is dietary LA, although we may all be LA saturated.

There is an extraordinarily strong correlation between the conversion of LA->AA and insulin resistance in adult human beings IRL. If you retain the LA, you are fine. If it gets converted, you are hosed. Why should those getting hosed eat more LA? pdf.sciencedirectassets.com/782868/1-s2.0-…

What if for some people. Those who have genetically low D6D activity, linoleic acid was beneficial. But for those with HIGH D6D activity linoleic acid was detrimental. And if the population was closish to 50:50. Then when you do a study on dietary linoleic the result is meh.

This isn’t idle speculation. Keeping D6D genotypes balanced in a population is a useful evolutionary strategy. Those who go North (away from equator) would benefit from increased D6D. Those who go South would benefit from low D6D activity. Natural selection decides.

My goal is simple: 1% better every day. Small wins add up.

I am VERY excited to be part of the Metabolic Gathering 2025. It will be fun to meet some of you in Naxos, Greece in October!

I am honored to be a presenter at Metabolic Gathering 2025. ketOntrack is hosting and L. Amber O'Hearn and Josh Rainer will be there as well. Three days of discussion, debate and workshopping. Naxos is a lovely destination to meet some of you IRL. ketontrack.com/metabolic-gath…

I’m very excited to meet with a handful of people with a lifetime of experiences thinking about diet, living in their own bodies, experimenting in their own realities and being willing to share their own experience.

This is a topic I’d like to expand on in Naxos!!!

This is really very dark. Are you OK? Just checking in. We’ll make it 100 years barring asteroid impact. More people will be fat if we continue to allow plastics/PUFA/pesticides and other endocrine disruptors in our food supply.

Amazing post. Hilarious takedown of Elon no matter which side of the debate you are on. I VERY rarely post anything political but this is worth listening to. It's FUNNY!! youtube.com/watch?v=0QVAbJ…

Have you heard this?! 😂 OMG, amazing!! Sure, it could be about me. If you can’t laugh at yourself you don’t belong here!! Amazing work, Jesse Wellens youtu.be/8Y6cgQNGOMg?si…

This song is SO much more than I originally let on. Supplement sales, etc. You'll see. How can I not have a sense of humor about this? This is straight solid gold.