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What if this was a drug ?🙂 🆕 NEJM | June 2025 🎯 CHALLENGE Trial: Structured exercise after adjuvant chemo in colon cancer 📦 RCT | n=889 | Median FU: 7.9 yrs 🟠 3-yr structured aerobic program vs health ed alone 📈 Primary Endpoint: Disease-Free Survival (DFS) 🔹 HR 0.72

Kudos to NEJM for publishing a non-drug intervention. Exercise improves both disease free & overall survival for patients with colon cancer who finished surgery & chemotherapy.

#ASCO25 #OncTwitter #crcsm NEW: Randomized trial of exercise vs health ed in people w/ colon cancer post adjuvant chemo: disease-free (HR 0.72; 6.4% abs diff at 5y) & overall (HR 0.63; 7.1% abs diff at 8y) survival improved w/ exercise! NNT ~14. ACTUALLY tolerable. 🏆 #OncoAlert

#ASCO25 #plenary If the graph on the left is practice changing, the graph on the right is urgently practice changing. Cost to health systems-$15K to $18K a month vs $100-$150 a month. ATOMIC trial vs CHALLENGE trial.

Such a well deserved standing ovation for Chris Booth and the Challenge trial. These data are quite powerful. Much stronger evidence than what we saw in plenaries today. #ASCO25

A standing ovation for #CHALLENGE trial at #ASCO25 - first in world to definitively show exercise reduces recurrence and improves survival: “For every 16 people, exercise prevents 1 person from recurrent/new cancer” “For every 14 people, exercise prevents 1 person from dying”

Exercise is medicine. #ASCO25

Dr Kathryn Schmitz ASCO Thank you Dr Kathryn Schmitz for posting. We created a video companion for the CHALLENGE Trial results here: x.com/oncologytube/s…

Interested in new therapies for melanoma? Dr. Jason Luke Jason Luke, MD, FACP presents at an Ed Session this afternoon ASCO. UPMC UPMC Physician Resources

My chat with Breastcancer.org at ASCO breastcancer.org/podcast/making…

So honored! See you at ACRM

My book, Moving Through Cancer, has been translated into Chinese!

🚨 STELLAR-303 makes history! First-ever Ph3 trial to show OS benefit of IO in MSS CRC 🎯 Years of grit & belief led us here 🥹 Endless thanks to Exelixis⁩ for the trust & Dr. Hecht for leading this global win with me! 🎉 ⁦UPMC Hillman Cancer Center⁩ ir.exelixis.com/news-releases/…

.UPMC Hillman Cancer Center, University of Pittsburgh melanoma researcher receives endowed immunotherapy award cancerletter.com/in-brief/20250…

A $1.5M gift from grateful patient, Jacqueline "Jackie" Shoener, will advance sarcoma research at UPMC Hillman Cancer Center through the establishment of the Dr. John A. Shoener Family Endowed Research Fund for Sarcoma. Read what inspired Jackie's gift: hillmanpowerofhope.org/stories-of-hop…

Anwaar Saeed UPMC Hillman Cancer Center Incredible milestone for MSS CRC! 🙌 Congratulations to Anwaar Saeed, Dr. Hecht, and the entire STELLAR-303 team on this historic achievement. A huge leap forward for IO in GI oncology. Truly inspiring work! 👏🎯 #CRC #Immunotherapy #STELLAR303 #OncologyInnovation

📰 New Science Signaling article from Vascular Medicine Institute and UPMC Hillman Cancer Center researchers suggests STIM2 loss may be a biomarker of more aggressive colorectal cancer. Read more👇

🗓️Join us Monday, August 4, 2025, for the Survivorship After Cancer of the Head and Neck: A Multidisciplinary Symposium — hosted at The Assembly, Thomas E. Richards Auditorium in Pittsburgh, PA, with both in-person and virtual options available. Pitt Oto UPMC Hillman Cancer Center

It's easy to recommend exercise for better overall health but I had a truly remarkable day in clinic empowering patients with colon cancer to follow an evidence-based, post-op fitness program that offers a survival benefit on par with some chemo drugs Bodies in motion, indeed!

So proud of this remarkable work from the Meisel lab UPMC Hillman Cancer Center Exercise-induced microbiota metabolite enhances CD8 T cell antitumor i... sciencedirect.com/science/articl…