Happy to share one extended side bit of my PhD at Bray Lab ! 🎉

Our review on #Drosophila #muscle #stem cells is just published Cells MDPI 👍👌💪, Catch up with the recent findings reported with this wonderful model 🪰🪰🪰

It’s great to see this out in the wild! A weird observation made 4 years ago turned into finding gastrulation influences levels of Notch dependent transcription, acting downstream of pathway activation and likely involving changes in the nucleus 🪰🎢

Earlier this month some of my PhD research with Bray Lab was published in Development . Here we were researching how cells communicate with each other. Specifically, we looked at how cells use the Notch signalling pathway.

On #TechnicalTuesday we’re highlighting the OptIC-Notch tool from Jonty Townson Bray Lab based on the BLITz approach. The authors used this optogenetic methid to temporally interrogate the interaction between NICD and CSL. 📖Development: journals.biologists.com/dev/article/15…

Dynamic modes of Notch transcription hubs conferring memory and stochastic activation revealed by live imaging the co-activator Mastermind biorxiv.org/cgi/content/sh… #bioRxiv

Haven't been on the platform much recently, but getting to spend 6 months in the Bray Lab, learning about the exciting science and interacting with the amazing folks in the lab like Javier de Haro Arbona is worthy of posting! Check out some of what they have been up to.

I'm proud to share our new pre-print! In the Bray Lab we've used Single Molecule tracking to study the dynamics of transcription factor CSL in #drosophila salivary glands. We show increased local exploration near targets in response to #Notch signaling! doi.org/10.1101/2023.0…

Imaging experiments reveal the complex and dynamic nature of the transcriptional hubs associated with Notch signalling. elifesciences.org/articles/93706…

Dynamic modes of Notch transcription hubs conferring memory and stochastic activation revealed by live imaging the co-activator Mastermind doi.org/10.7554/eLife.…

Excited to share my postdoctoral work is now online Cell thanks to all the coauthors that contributed to this work!

Great poster session after this afternoon’s fantastic sessions on Cell dynamics and Stem cells and regeneration at #DrosoSpain2024

Delighted that this cool story about the role of transcriptional hubs in Notch signaling, led by Javier de Haro Arbona is now final VoR #elife. Thanks too to @drosoigmm for the accompanying insight.

Really cool story by the Bray Lab now VoR eLife - the journal with an #insight by @drosoigmm 👇🏻👇🏻👇🏻

Bray Lab Javier de Haro Arbona @drosoigmm Congratulations to all the people involved 👏👏👏great and beautiful work

Live imaging studies of fruit fly cells sheds light on how dynamic aggregates known as transcription hubs participate in a signalling pathway important for development. elifesciences.org/digests/92083/…

✨Pre-print time!✨ Excited to share Kirstin Meyer’s latest work showing how Yap charge patterning mediates transcriptional co-condensate formation! Fantastic collab with Bo Huang Lab, Kiersten Ruff, & Xiaokun Shu 🤩 biorxiv.org/content/10.110…

Delighted to have joined preLights and to have published my first post! I really enjoyed reading this #preprint on how #ER exit sites regulate the composition of P bodies. (1/2)