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Pleomorphic cells with abundant pink cytoplasm in a lymph node #FNA, h/o follicular lymphoma. CD163 stain bottom left. Positive for clonal IgH rearrangement. S/O'ed as 'Malignant histiocytic neoplasm c/w histiocytic transformation of follicular lymphoma.' #cytology #cytopath

“Solid-Pseudopapillary Neoplasm (SPN)”, Pancreatic FNA.

Classic morphology for sclerosing epithelioid fibrosarcoma (SEF): #pathtwitter #surgpath #BSTpath

Infarct necrosis important to separate from true tumour necrosis in NETs.2 show true necrosis(abrupt transition, karyorrhectic debris, comedo-like)& 2 show infarct(gradual transition, zonal granulation tissue/myobroblasts) If you think easy -> retweet If you think hard -> like

#GUpath🧩time! adult human with renal mass, no prior malignancies, undergoes radical nephrectomy showing a chromophobe RCC 👀🔬anything?🤨

Hello #BreastPath friends! Spotted an interesting staining pattern—CK5/6 (3rd pic) is trying to tell me something in this intraductal proliferation, but I don’t speak its language. ER (last pic) is also in the mix. Awesome brains?

A bronchial brushing from an incidental lesion. What do you think the smear most likely represents?🧐🧐 A) a granulomatous process B) a carcinoid tumor C) a granular cell tumor D) alveolar macrophages #CytoPath #PathTwitter #Pathology #PulmPath

ALK-positive histiocytosis of the breast is a rare tumor that can mimic other inflammatory neoplasms or processes, such as inflammatory myofibroblastic tumor, cellular spindled histiocytic pseudotumor (among others). #BSTPath, #UmichPath, #BSTpathGoBlue

This insane epithelioid hemangioendothelioma arose in the neck and has a lymphoid cuff - both of which mimic epithelioid hemangioma. CAMTA is confirmatory. Note the intracytoplasmic lumen with an erythrocyte (arrow).

Great teaching points. speckled pattern 👍

Case of Invasive Papillary Carcinoma 🔬 Invasive papillary carcinoma shows an infiltrative and complex growth of epithelial cells on arborizing fibrovascular stalks. #PathX #PathTwitter #breastpath

Clear cell stromal tumor of the lung. New kid on the block in #BSTPath. Don't let yourself fooled by the name ➡️ prominent clear cell cytoplasm only in a minority of cases. Dr. Dei Tos at the #BST pathology course in Barcelona, Spain #PathTwitter #HMAR_BASTPC25

What is your top morphologic diagnosis for this renal mass with unique histology? #GUPath #OnePicDx 🔬 Answer in comment 👇🏻👇🏻👇🏻

Just a cute "Cockle burr" (hematoidin crystals often seen in pregnant patients on a PAP test. (SurePath)

Enteric yolk sac tumor This extensively necrotic anterior abdominal mass shows positive CDX2, KRT8/18, and SALL4, all features identical to enteroblastic Ca. If enteric type yolk sac tumor presents as a metastasis of unknown origin, only isochromosome 12p testing tells the truth.

What’s the diagnosis of this breast lesion associated with microcalcifications? 🔬 Poll in the comments 👇 Answer to be posted on Monday #PathX #PathTwitter #breastpath #PathQuiz

"Wiry vessels and sticky hepatocytes". Well-differentiated "Hepatocellular Carcinoma", (Liver, FNA)

Breast mass diagnosis? Confirmatory IHCs? #PathX #breastpath #pathresidents #pathtwitter #BreastPatholog1 Columbia Pathology Columbia Pathology Residency ISBP

THYROID with metastatic lung "Small Cell Carcinoma". Macrophages provide a good size reference. DD - Medullary CA uncommonly may have a "small cell" phenotype as well as mets from other neuroendocrine tumors (I've seen at least two cases of Merkel cell CA mets to thyroid). (FNA)

Malignant Phyllodes Tumor of the Breast With Multiple Cutaneous Metastasis Resembling Pleomorphic Rhabdomyosarcoma pubmed.ncbi.nlm.nih.gov/39660950/