Really proud of this work by Jae Kennemur and Yueming Long. #Enzymes rock, with a little help from #directedevolution to do #chemistry not known in nature (and not easily done by humans).

Something a little different from our group. We designed a regeneration system for ATP(gamma)S, a reagent that normally costs ~$30,000/g. This allows for more practical enzymatic thiophosphorylation to make a number of interesting/funky thiophosphates. chemrxiv.org/engage/chemrxi…

I was very excited that our AI Institute for Molecule Synthesis (MMLI) got renewed for another 5 years. See: NSF announces $100 million investment in National Artificial Intelligence Research Institutes awards to secure American leadership in AI nsf.gov/news/nsf-annou…

Fantastic to meet up with so many former #Arnoldgroup members at the 2025 #ProteinEngineering Gordon conference at Bryant University. #GRC meetings are so great! So is protein engineering.

Congrats to our former postdoc Jian Li on this elegant solution to epoxidizing the internal double bond of farnesol (with enzyme of course!). The shortest synthesis of subglutinol-type meroterpenoids to date. science.org/doi/10.1126/sc…

Our new company, K2 Therapeutics, is off to the races to develop antibody drugs that target multipass membrane proteins. We are hiring so check us out! k2-tx.com/home#careers

More on copper catalysis in nonheme enzymes: we have engineered hydroxymandelate synthase to catalyze alkene oxytrifluoromethylation, generating a broad range of chiral trifluoromethyl-containing β-, γ-, and δ-lactones with high enantioselectivity (pubs.acs.org/doi/full/10.10…). This

Another exciting milestone in biocatalysis with nonheme enzymes! We have developed the first enzymatic system for copper-catalyzed radical C(sp³)–N coupling: science.org/doi/full/10.11…, which also represents the first demonstration of employing pterin-dependent nonheme enzymes in

Check out our new perspective "Illuminating the universe of enzyme catalysis in the era of artificial intelligence" now out in Cell Systems ! We discuss a vision and path forward for genetically encoding almost all chemistry, powered by new AI tools: authors.elsevier.com/c/1lg4h8YyDfuZ…

I think we will soon have AI tools to genetically encode--i.e., make #enzymes for--many useful chemical transformations. On our way to getting biology to do all the chemistry we love (and think only humans can do). #directedevolution #MLDE #proteindesign

Sequence-Based Generative AI-Guided Design of Versatile Tryptophan Synthases 1. A groundbreaking study leverages GenSLM, a protein language model, to design novel tryptophan synthase β-subunits (TrpBs) with enhanced activity and substrate promiscuity. This approach bypasses

Private tour of the Louvre is a special treat. They were vacuuming the Sphinx.

A compelling review of how ML/AI could help in the quest to find an enzyme for every reaction. Jason Yang Francesca-Zhoufan Li Yueming Long Frances Arnold

Very pleased to see our AI model GenSLM designing novel and versatile enzymes in a challenging setting in Frances Arnold lab. biorxiv.org/content/10.110… Back in 2022, we built the world's first genome-scale language model (GenSLM) trained on all known bacterial and viral genomes

In this perspective, we discuss a vision for AI-driven #enzyme discovery to unveil a world of enzymes that transcends biological evolution and perhaps offers a route to genetically encoding almost any chemistry. cell.com/cell-systems/a…

Speaking under the gaze of the emperor. Haven't done that before...lovely to be in #Vienna.

Really cool paper from Frances Arnold cell.com/cell-systems/a…

Exciting work!

The posting is unfortunately not super clear on this, but please apply if you want to do BioML research, especially around machine learning for molecular biology and bioengineering! I get sad if there are no applicants with this profile in the pool!

Congratulations Soumitra Soumitra Athavale !! Love #enzymes and how they are so versatile, with the right insights of course.